Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation.
Animals
Cell Proliferation
/ genetics
Cytochrome P450 Family 2
/ genetics
DNA Methylation
/ genetics
Female
Gene Expression
/ genetics
Gene Expression Regulation
/ genetics
Glucosephosphate Dehydrogenase
/ genetics
Hypertension, Pulmonary
/ genetics
Hypoxia
/ genetics
Lung
/ metabolism
Male
Mice
Muscle, Smooth, Vascular
/ metabolism
Myocytes, Smooth Muscle
/ metabolism
Phenotype
Pulmonary Artery
/ metabolism
RNA, Long Noncoding
/ genetics
Up-Regulation
/ genetics
NADPH
PPP
metabolim
pulmonary
smooth muscle cells
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
pubmed:
12
3
2020
medline:
17
7
2020
entrez:
12
3
2020
Statut:
ppublish
Résumé
Metabolic reprogramming is considered important in the pathogenesis of the occlusive vasculopathy observed in pulmonary hypertension (PH). However, the mechanisms that link reprogrammed metabolism to aberrant expression of genes, which modulate functional phenotypes of cells in PH, remain enigmatic. Herein, we demonstrate that, in mice, hypoxia-induced PH was prevented by glucose-6-phosphate dehydrogenase deficiency (G6PD
Identifiants
pubmed: 32159369
doi: 10.1152/ajplung.00001.2020
pmc: PMC7191486
doi:
Substances chimiques
RNA, Long Noncoding
0
Glucosephosphate Dehydrogenase
EC 1.1.1.49
Cytochrome P450 Family 2
EC 1.14.14.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
L773-L786Subventions
Organisme : NCI NIH HHS
ID : P50 CA058187
Pays : United States
Organisme : Cancer Research UK
ID : C5759/A17098
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C480/A1141
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL114887
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132574
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL014985
Pays : United States
Références
Sci Transl Med. 2017 Oct 25;9(413):
pubmed: 29070699
Anal Biochem. 2016 Feb 1;494:55-67
pubmed: 26576833
Genome Biol. 2013;14(9):R104
pubmed: 24070194
Antioxid Redox Signal. 2018 Jan 20;28(3):251-272
pubmed: 28648096
Circulation. 2013 Oct 29;128(18):2047-57
pubmed: 24077167
J Immunol. 2014 Jul 15;193(2):597-609
pubmed: 24928992
PLoS One. 2018 Aug 30;13(8):e0203493
pubmed: 30161219
J Med Chem. 2012 May 10;55(9):4431-45
pubmed: 22506561
PLoS One. 2016 Mar 03;11(3):e0150480
pubmed: 26937637
Biol Rev Camb Philos Soc. 2015 Aug;90(3):927-63
pubmed: 25243985
Diabetes. 2006 Nov;55(11):2939-49
pubmed: 17065329
Mol Cell. 2015 Feb 19;57(4):662-673
pubmed: 25601757
Sci Signal. 2009 Nov 17;2(97):ra73
pubmed: 19920251
Circulation. 2010 Jun 29;121(25):2747-54
pubmed: 20547927
Circulation. 2017 Dec 19;136(25):2468-2485
pubmed: 28972001
Int J Mass Spectrom. 2015 Feb 15;378:347-359
pubmed: 25866469
J Biol Chem. 1998 Apr 24;273(17):10609-17
pubmed: 9553122
Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H944-H957
pubmed: 27591215
J Physiol. 2019 Feb;597(4):1103-1119
pubmed: 29920674
Epigenetics. 2012 Jun 1;7(6):567-78
pubmed: 22534504
Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L287-300
pubmed: 25480333
Am J Hematol. 2010 Feb;85(2):124-7
pubmed: 20029989
Cell Metab. 2017 Jul 5;26(1):131-141
pubmed: 28683280
Pediatr Blood Cancer. 2010 Mar;54(3):398-402
pubmed: 19827138
Am J Physiol Heart Circ Physiol. 2013 Feb 15;304(4):H491-500
pubmed: 23241320
J Biol Chem. 1992 Apr 5;267(10):6999-7006
pubmed: 1348057
Biochem Genet. 1988 Feb;26(1-2):89-103
pubmed: 3377761
J Appl Physiol (1985). 2015 Nov 15;119(10):1164-72
pubmed: 25930027
Circulation. 2016 Oct 11;134(15):1105-1121
pubmed: 27562971
J Immunol. 2011 Sep 1;187(5):2711-22
pubmed: 21813768
Am J Respir Cell Mol Biol. 2014 Jun;50(6):1084-95
pubmed: 24392990
J Biol Chem. 2012 Sep 14;287(38):32006-16
pubmed: 22822071
Science. 2017 Feb 24;355(6327):842-847
pubmed: 28104796
Circulation. 2002 Jan 15;105(2):244-50
pubmed: 11790708
Science. 2009 May 15;324(5929):930-5
pubmed: 19372391
Nat Rev Cancer. 2013 Aug;13(8):572-83
pubmed: 23822983
Circulation. 2017 Dec 19;136(25):2451-2467
pubmed: 28971999
Cell Rep. 2016 May 17;15(7):1566-1579
pubmed: 27160912
J Biol Chem. 2003 Aug 22;278(34):32100-6
pubmed: 12777375
Pulm Circ. 2016 Sep;6(3):360-8
pubmed: 27683613
Antioxid Redox Signal. 2018 Jan 20;28(3):230-250
pubmed: 28637353
Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L545-56
pubmed: 25063801
Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H904-H912
pubmed: 27521420
J Biol Chem. 2011 Mar 18;286(11):8977-87
pubmed: 21212270
J Biol Chem. 2010 Apr 23;285(17):12840-50
pubmed: 20178979
Clin Chest Med. 2007 Mar;28(1):23-42, vii
pubmed: 17338926
J Pharmacol Exp Ther. 2002 Apr;301(1):299-305
pubmed: 11907187
Arch Dis Child. 1992 Apr;67(4 Spec No):388-92
pubmed: 1586176
Cell Metab. 2015 Apr 7;21(4):596-608
pubmed: 25863249