Original and generic preservation solutions in organ transplantation. A new paradigm?


Journal

Acta cirurgica brasileira
ISSN: 1678-2674
Titre abrégé: Acta Cir Bras
Pays: Brazil
ID NLM: 9103983

Informations de publication

Date de publication:
2020
Historique:
received: 06 09 2019
accepted: 05 12 2019
entrez: 12 3 2020
pubmed: 12 3 2020
medline: 24 3 2020
Statut: epublish

Résumé

Solid organ transplantation is a very complex process, in which the storage of the graft in a preservation solution is mandatory in order to extend ischemic times and contain further damage. The condition in which the organ is transplanted is critical for the outcome of the organ recipient. The recent emergence of generic versions of organ preservation solutions (solutions with the same composition and under the same legislation as the original versions, but with different brands) compelled us to study whether the standards are maintained when comparing the original and its generic counterpart. Along these lines, we discuss and comment on some aspects concerning this issue of general interest in the organ transplantation field.

Identifiants

pubmed: 32159587
pii: S0102-86502020000100400
doi: 10.1590/s0102-865020200010000001
pmc: PMC7065442
pii:
doi:

Substances chimiques

IGL-1 solution 0
Organ Preservation Solutions 0
Glutathione GAN16C9B8O
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202000101

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Auteurs

Joan Roselló-Catafau (J)

PhD, Experimental Pathology Department, Institute of Biomedical Research (IIBB-CSIC), Catalonia, Barcelona, Spain. Manuscript writing, final approval.

Arnau Panisello-Roselló (A)

PhD, Experimental Pathology Department, Institute of Biomedical Research (IIBB-CSIC), Catalonia, Barcelona, Spain. Manuscript writing, final approval.

Gianfranco Pasut (G)

PhD, Department of Pharmaceutical and Pharmacological Sciences, Padova, Italy. Manuscript writing, final approval.

Miquel Navasa (M)

PhD, Liver Transplantation Unit, Hospital Clínic, Barcelona, Catalonia, Spain. Manuscript writing, final approval.

Jacques Pirenne (J)

PhD, Abdominal Transplant Surgery UZ Leuven, University Hospitals Leuven, Belgium. Manuscript writing, final approval.

René Adam (R)

PhD, Centre Hépatobiliare, AP-HP Hôpital Paul Brousse, Inserm U935, Université Paris-Sud, Villejuif, France. Manuscript writing, final approval.

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Classifications MeSH