Arthrogenic human synovial cysts: immunohistochemical profile of interleukin-1beta, interleukin-6, tumour necrosis factor-alpha.
immunohistochemistry
interleukins 1beta and 6
synovial cysts
tumour necrosis factor-alpha
Journal
Folia morphologica
ISSN: 1644-3284
Titre abrégé: Folia Morphol (Warsz)
Pays: Poland
ID NLM: 0374620
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
10
2019
accepted:
28
11
2019
revised:
20
11
2019
pubmed:
12
3
2020
medline:
16
10
2021
entrez:
12
3
2020
Statut:
ppublish
Résumé
Synovial cysts are currently classified as degenerative lesions affecting the joint capsule or adjacent structures. In our study we describe the results obtained in an immunohistochemical study comprising 18 patients with synovial cysts, performed to evaluate the pathophysiological role of some inflammatory cytokines such as: interleukin (IL)-1β, IL-6 and tumour necrosis factor-alpha (TNF-α). Results showed an over-expression of TNF-α, IL-1β and IL-6 which appears to be involved in the onset and progression of the disease. At the present time it is not possible to affirm that these molecules play a direct role also due to the absence of further and more specific investigations. The authors therefore hypothesize that inhibition of inflammation may have a significant role in the pathogenesis and regression of synovial cysts. Hence, these inflammatory cytokines may be considered potential therapeutic targets. The development of synthetic inhibitors of these inflammatory factors could lead to a reduction in the intensity of inflammation, thus inhibiting the onset and development of the disease.
Sections du résumé
BACKGROUND
BACKGROUND
Synovial cysts are currently classified as degenerative lesions affecting the joint capsule or adjacent structures.
MATERIALS AND METHODS
METHODS
In our study we describe the results obtained in an immunohistochemical study comprising 18 patients with synovial cysts, performed to evaluate the pathophysiological role of some inflammatory cytokines such as: interleukin (IL)-1β, IL-6 and tumour necrosis factor-alpha (TNF-α).
RESULTS
RESULTS
Results showed an over-expression of TNF-α, IL-1β and IL-6 which appears to be involved in the onset and progression of the disease. At the present time it is not possible to affirm that these molecules play a direct role also due to the absence of further and more specific investigations. The authors therefore hypothesize that inhibition of inflammation may have a significant role in the pathogenesis and regression of synovial cysts.
CONCLUSIONS
CONCLUSIONS
Hence, these inflammatory cytokines may be considered potential therapeutic targets. The development of synthetic inhibitors of these inflammatory factors could lead to a reduction in the intensity of inflammation, thus inhibiting the onset and development of the disease.
Identifiants
pubmed: 32159845
pii: VM/OJS/J/66237
doi: 10.5603/FM.a2020.0025
doi:
Substances chimiques
Interleukin-1beta
0
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM