Left-hemispheric predominance of nigrostriatal deficit in isolated REM sleep behavior disorder.

Adult Aged Corpus Striatum / metabolism Dopamine / metabolism Dopamine Plasma Membrane Transport Proteins / metabolism Female Humans Male Middle Aged Neuroimaging / methods Parkinson Disease / metabolism Putamen / diagnostic imaging REM Sleep Behavior Disorder / diagnosis Substantia Nigra / diagnostic imaging Ultrasonography, Doppler, Transcranial / methods

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
14 04 2020
Historique:
received: 24 03 2019
accepted: 17 10 2019
pubmed: 13 3 2020
medline: 14 8 2020
entrez: 13 3 2020
Statut: ppublish

Résumé

Unilateral onset of parkinsonism due to nigrostriatal damage of the contralateral hemisphere is frequent in Parkinson disease (PD). There is evidence for a left-hemispheric bias of motor asymmetry in right-handed patients with PD indicating a hemispheric dominance. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of PD and other synucleinopathies. To test the hypothesis that right-handed patients with IRBD exhibit left-hemispheric predominance of subclinical nigrostriatal dysfunction, we evaluated this aspect using neuroimaging instruments. In 167 right-handed patients with IRBD without parkinsonism, we evaluated in each hemisphere the integrity of the striatal dopaminergic terminals by dopamine transporter (DAT)-SPECT and the substantia nigra echogenicity by transcranial sonography. DAT-SPECT showed lower specific binding ratio (SBR) in the left striatum and left caudate nucleus than in the right striatum and right caudate nucleus. The percentage of patients with lower SBR was greater in the left striatum and left caudate nucleus than in the right striatum and right caudate nucleus. In those who developed a synucleinopathy in <5 years from DAT-SPECT, there was a lower SBR in the left putamen and left caudate nucleus than in the right putamen and right caudate nucleus. Substantia nigra echogenic size was greater in the left than in the right side in patients with hyperechogenicity and among individuals who phenoconverted in <5 years from transcranial sonography. Right-handed patients with IRBD exhibit left-hemispheric predominance of subclinical nigrostriatal dysfunction. In premotor PD, the neurodegenerative process begins asymmetrically, initially impairing the nigrostriatal system of the dominant hemisphere.

Identifiants

DOI: 10.1212/WNL.0000000000009246 PMID: 32161031
pubmed: 32161031
pii: WNL.0000000000009246
doi: 10.1212/WNL.0000000000009246
doi:

Substances chimiques

Dopamine Plasma Membrane Transport Proteins 0
Dopamine VTD58H1Z2X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1605-e1613

Informations de copyright

© 2020 American Academy of Neurology.

Auteurs

Alex Iranzo (A)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain. airanzo@clinic.cat.

Ambra Stefani (A)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Aida Niñerola-Baizan (A)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.
ORCID: 0000-0002-7306-5775

Heike Stokner (H)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Monica Serradell (M)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Dolores Vilas (D)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Evi Holzknecht (E)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Carles Gaig (C)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Javier Pavia (J)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Francesc Lomeña (F)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

David Reyes (D)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Klaus Seppi (K)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Joan Santamaria (J)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Birgit Högl (B)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Eduard Tolosa (E)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

Werner Poewe (W)

From the Sleep Disorders Center (A.I., M.S., D.V., C.G., D.R., J.S.) and Movement Disorders Unit (E.T.), Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain; Department of Neurology (A.S., H.S., E.H., K.S., B.H., W.P.), Medical University Innsbruck, Austria; Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (A.N.-B., J.P.); and Nuclear Medicine Service (J.P., F.L.), Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la dopamine › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Néostriatum › Putamen › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Parasomnies › Parasomnies du sommeil paradoxal › Trouble du comportement en sommeil paradoxal › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Substantia nigra › Left-hemispheric predominance of nigrostriatal...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroradiographie › Échoencéphalographie › Échographie-doppler transcrânienne › Left-hemispheric predominance of nigrostriatal...