PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.
Anti-Retroviral Agents
/ therapeutic use
Argonaute Proteins
/ genetics
CD4-Positive T-Lymphocytes
/ virology
Epigenesis, Genetic
Gene Expression Regulation, Viral
/ drug effects
HEK293 Cells
HIV Infections
/ virology
HIV-1
/ genetics
Histone Deacetylases
/ genetics
Humans
Jurkat Cells
RNA-Binding Proteins
Repressor Proteins
/ genetics
Viral Proteins
/ metabolism
Virus Latency
/ drug effects
Virus Replication
/ drug effects
HDAC4
HIV-1 latency
PIWIL4
epigenetics
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
04 05 2020
04 05 2020
Historique:
received:
13
11
2019
accepted:
21
02
2020
pubmed:
13
3
2020
medline:
27
10
2020
entrez:
13
3
2020
Statut:
epublish
Résumé
Although substantial progress has been made in depicting the molecular pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection, the comprehensive mechanism of HIV-1 latency and the most promising therapeutic strategies to effectively reactivate the HIV-1 latent reservoir to achieve a functional cure for AIDS remain to be systematically illuminated. Here, we demonstrated that piwi (P element-induced Wimpy)-like RNA-mediated gene silencing 4 (PIWIL4) played an important role in suppressing HIV-1 transcription and contributed to the latency state in HIV-1-infected cells through its recruitment of various suppressive factors, including heterochromatin protein 1α/β/γ, SETDB1, and HDAC4. The knockdown of PIWIL4 enhanced HIV-1 transcription and reversed HIV-1 latency in both HIV-1 latently infected Jurkat T cells and primary CD4
Identifiants
pubmed: 32161174
pii: JVI.01923-19
doi: 10.1128/JVI.01923-19
pmc: PMC7199406
pii:
doi:
Substances chimiques
Anti-Retroviral Agents
0
Argonaute Proteins
0
PIWIL4 protein, human
0
RNA-Binding Proteins
0
Repressor Proteins
0
Viral Proteins
0
HDAC4 protein, human
EC 3.5.1.98
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
Références
FEBS Lett. 2014 Nov 28;588(23):4297-304
pubmed: 25220675
PLoS Pathog. 2009 Jun;5(6):e1000495
pubmed: 19557157
Cell Res. 2011 Mar;21(3):381-95
pubmed: 21321607
Science. 2004 Mar 12;303(5664):1626-32
pubmed: 15016989
Nat Commun. 2016 Jun 13;7:11730
pubmed: 27291871
J Cell Biochem. 2015 Dec;116(12):2744-54
pubmed: 26205624
Genes Dev. 2006 Jul 1;20(13):1732-43
pubmed: 16766679
Nucleic Acids Res. 2011 Aug;39(15):6596-607
pubmed: 21546553
Mol Cell. 2007 Oct 12;28(1):1-13
pubmed: 17936700
J Clin Immunol. 2001 May;21(3):218-26
pubmed: 11403229
Nat Med. 2014 Apr;20(4):425-9
pubmed: 24658076
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2284-93
pubmed: 22826225
EMBO J. 2007 Jan 24;26(2):412-23
pubmed: 17245431
J Immunol. 2016 Feb 15;196(4):1591-603
pubmed: 26755820
Hepatology. 2014 Sep;60(3):798-806
pubmed: 24930433
Nucleic Acids Res. 2019 Apr 8;47(6):3013-3027
pubmed: 30788509
Science. 1997 Nov 14;278(5341):1291-5
pubmed: 9360926
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13193-7
pubmed: 9371822
Nat Rev Microbiol. 2014 Nov;12(11):750-64
pubmed: 25402363
Retrovirology. 2009 Dec 04;6:111
pubmed: 19961595
Autophagy. 2020 Apr;16(4):683-697
pubmed: 31242129
EMBO J. 2004 Dec 8;23(24):4727-37
pubmed: 15565169
Cancer Lett. 2012 Feb 1;315(1):12-7
pubmed: 22047710
Science. 2004 Sep 3;305(5689):1434-7
pubmed: 15284453
J Biol Chem. 2012 Dec 14;287(51):42708-25
pubmed: 23086926
Lancet HIV. 2014 Oct;1(1):e13-21
pubmed: 26423811
J Biol Chem. 2013 Sep 6;288(36):25995-6003
pubmed: 23884411
Virology. 2013 Jun 5;440(2):182-9
pubmed: 23541084
Antimicrob Agents Chemother. 2002 Jun;46(6):1896-905
pubmed: 12019106
Nucleic Acids Res. 2014 Aug;42(14):8984-95
pubmed: 25038252
J Virol. 2016 Mar 28;90(8):3966-3980
pubmed: 26842467
Cell Death Dis. 2018 Mar 19;9(4):423
pubmed: 29555935
Methods Mol Biol. 2005;304:3-15
pubmed: 16061962
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2282-2289
pubmed: 30670656
J Virol. 2004 Jun;78(11):5670-8
pubmed: 15140964
Front Microbiol. 2017 Jan 30;8:80
pubmed: 28194140
EMBO J. 2003 Apr 15;22(8):1868-77
pubmed: 12682019
PLoS One. 2012;7(8):e43816
pubmed: 22952772
PLoS Genet. 2011 Mar;7(3):e1001354
pubmed: 21483810
Nucleic Acids Res. 2015 Dec 2;43(21):10474-91
pubmed: 26405199
Mol Ther. 2013 Feb;21(2):368-79
pubmed: 23183536
Nature. 2006 Jul 13;442(7099):203-7
pubmed: 16751777
Cell. 2013 Oct 24;155(3):519-29
pubmed: 24243012
Genes Dev. 2006 Jul 1;20(13):1709-14
pubmed: 16766680
J Virol. 2016 Oct 14;90(21):9712-9724
pubmed: 27535056
AIDS. 2002 Jul 26;16(11):1479-87
pubmed: 12131185
J Biol Chem. 2018 Aug 3;293(31):12177-12185
pubmed: 29887524
PLoS One. 2015 Aug 25;10(8):e0136801
pubmed: 26305553
Cell. 2019 Oct 17;179(3):632-643.e12
pubmed: 31607510
J Virol. 1998 Apr;72(4):2855-64
pubmed: 9525605
Science. 2006 Jul 21;313(5785):363-7
pubmed: 16778019
BMB Rep. 2019 Mar;52(3):196-201
pubmed: 30103846
Nature. 2012 Jul 25;487(7408):439-40
pubmed: 22836995
Drug Discov Today. 2013 Jun;18(11-12):541-51
pubmed: 23270785
PLoS Pathog. 2015 Sep 17;11(9):e1005142
pubmed: 26379282
mBio. 2018 May 1;9(3):
pubmed: 29717016
Nucleic Acids Res. 2015 Apr 20;43(7):3712-25
pubmed: 25779046
PLoS Pathog. 2014 Nov 13;10(10):e1004473
pubmed: 25393648
Cell. 2007 Mar 23;128(6):1089-103
pubmed: 17346786
Elife. 2019 Jan 17;8:
pubmed: 30652970
Nat Med. 2003 Jun;9(6):727-8
pubmed: 12754504
Oncotarget. 2015 Jan 1;6(1):494-509
pubmed: 25504437
Oncogene. 2007 Feb 26;26(9):1351-6
pubmed: 17322921
Int J Dev Biol. 2009;53(2-3):291-301
pubmed: 19412888
Electrophoresis. 1998 Jun;19(8-9):1260-4
pubmed: 9694261
J Infect Dis. 2002 Nov 15;186(10):1403-11
pubmed: 12404155
J Clin Invest. 2013 Mar;123(3):1359-70
pubmed: 23434587
Science. 1997 Nov 14;278(5341):1295-300
pubmed: 9360927
Curr Opin Immunol. 1999 Aug;11(4):460-5
pubmed: 10448148
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18760-5
pubmed: 22065765
Nature. 2009 Oct 29;461(7268):1296-9
pubmed: 19812547
Biochem Biophys Res Commun. 2007 Aug 3;359(3):497-502
pubmed: 17544373
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4868-73
pubmed: 10220385
Cell. 2007 May 18;129(4):823-37
pubmed: 17512414
Cell. 2012 Apr 27;149(3):693-707
pubmed: 22541438
Nature. 2004 May 20;429(6989):318-322
pubmed: 15152257
PLoS Pathog. 2013;9(12):e1003834
pubmed: 24385908
RNA. 2011 Jun;17(6):1090-9
pubmed: 21515829
Eur J Cell Biol. 2017 Dec;96(8):746-757
pubmed: 28993008
Nat Struct Mol Biol. 2004 Jun;11(6):576-7
pubmed: 15156196
Nature. 1996 Nov 28;384(6607):375-8
pubmed: 8934526
Trends Biochem Sci. 2016 Aug;41(8):679-689
pubmed: 27263052
Nature. 2012 Jul 25;487(7408):482-5
pubmed: 22837004
Cell Host Microbe. 2017 May 10;21(5):569-579.e6
pubmed: 28494238
mBio. 2017 Feb 28;8(1):
pubmed: 28246360
J Biol Chem. 2010 May 28;285(22):16538-45
pubmed: 20335163
J Immunol. 2010 Aug 15;185(4):2009-12
pubmed: 20631304
Mol Biol Cell. 2018 Jan 15;29(2):220-233
pubmed: 29142071
Stroke. 2011 Apr;42(4):1105-9
pubmed: 21311060
Cell Rep. 2016 Sep 13;16(11):2819-2828
pubmed: 27626653
Cell. 2012 Nov 21;151(5):964-80
pubmed: 23159368
Nature. 2006 Jul 13;442(7099):199-202
pubmed: 16751776
RNA Biol. 2013 Apr;10(4):553-63
pubmed: 23563448
EMBO J. 2007 Jan 24;26(2):424-35
pubmed: 17245432
Cell. 2009 May 1;137(3):522-35
pubmed: 19395010
Genes Dev. 2010 Nov 15;24(22):2493-8
pubmed: 20966047
Elife. 2018 Jun 04;7:
pubmed: 29863470
J Virol. 2014 Apr;88(7):3612-22
pubmed: 24403582
J Virol. 2009 May;83(10):4749-56
pubmed: 19279091
J Virol. 2017 May 12;91(11):
pubmed: 28331090