Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney Failure.
cardiovascular disease
chronic kidney disease
end-stage kidney disease
myosteatosis
peritoneal dialysis
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
11
2019
accepted:
06
02
2020
entrez:
13
3
2020
pubmed:
13
3
2020
medline:
13
3
2020
Statut:
epublish
Résumé
Fat accumulation in skeletal muscle was recently established as a major risk factor for cardiovascular disease (CVD) in the general population, but its relevance for patients with kidney failure is unknown. Here we examined the potential association between muscle radiation attenuation (MRA), a non-invasive indicator of fat deposits in muscle, and cardiovascular events in patients with kidney failure treated with peritoneal dialysis (PD) and investigated dynamic changes and determinants of MRA in this population. We retrospectively assessed MRA on computed tomography images collected yearly in 101 incident patients with kidney failure starting PD between January 2006 and December 2015. After a median of 21 months on dialysis, 34 patients had 58 non-fatal cardiovascular events, and 22 patients had died. Baseline MRA was associated with cardiovascular events during time on dialysis, and patients with higher MRA (reflecting lower amounts of fat in muscle) showed a reduced incidence of CVD, independently of traditional risk factors (adjusted HR, 0.91; 95% CI, 0.86-0.97,
Identifiants
pubmed: 32161551
doi: 10.3389/fphys.2020.00130
pmc: PMC7053428
doi:
Types de publication
Journal Article
Langues
eng
Pagination
130Informations de copyright
Copyright © 2020 Keddar, Muylle, Carrie, Trefois, Nachit, Crott, Christiaens, Bammens, Jadoul, Goffin and Morelle.
Références
Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1087-F1108
pubmed: 27707707
J Clin Endocrinol Metab. 2012 Jul;97(7):E1099-105
pubmed: 22508709
Circulation. 2018 Mar 27;137(13):1391-1406
pubmed: 29581366
Diabetes Care. 2012 Jun;35(6):1355-60
pubmed: 22432118
J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1133-40
pubmed: 25838547
J Cachexia Sarcopenia Muscle. 2017 Oct;8(5):768-777
pubmed: 28712119
J Clin Oncol. 2013 Apr 20;31(12):1539-47
pubmed: 23530101
Am J Kidney Dis. 2010 Aug;56(2):348-58
pubmed: 20605303
Lancet Diabetes Endocrinol. 2019 Sep;7(9):715-725
pubmed: 31301983
Lancet Oncol. 2008 Jul;9(7):629-35
pubmed: 18539529
Kidney Int. 2013 May;83(5):878-86
pubmed: 23423258
Perit Dial Int. 2017 Jul-Aug;37(4):362-374
pubmed: 28676507
Physiol Rev. 2018 Oct 1;98(4):2133-2223
pubmed: 30067154
Circ J. 2018 Nov 24;82(12):3069-3075
pubmed: 30270315
Lancet Diabetes Endocrinol. 2019 Apr;7(4):313-324
pubmed: 30174213
Nephrol Dial Transplant. 2010 Nov;25(11):3773-8
pubmed: 20501456
J Clin Invest. 1981 Feb;67(2):563-8
pubmed: 7007440
Am J Kidney Dis. 2001 Jul;38(1):85-90
pubmed: 11431186
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2715-22
pubmed: 21885852
Circulation. 2007 Sep 11;116(11):1234-41
pubmed: 17709633
N Engl J Med. 2007 Nov 29;357(22):2277-84
pubmed: 18046031
J Am Soc Nephrol. 2013 Jan;24(1):88-99
pubmed: 23274953
Lancet. 2013 Jul 27;382(9889):339-52
pubmed: 23727170
Int J Obes (Lond). 2019 Jan;43(1):139-148
pubmed: 29717276
Clin Nutr. 2019 Aug 6;:
pubmed: 31439352
N Engl J Med. 2014 Sep 18;371(12):1131-41
pubmed: 25229917
Age Ageing. 2016 Jul;45(4):529-34
pubmed: 27076522
J Clin Invest. 2016 Jan;126(1):12-22
pubmed: 26727229
J Am Soc Nephrol. 2016 Sep;27(9):2861-71
pubmed: 26823551
Lancet Diabetes Endocrinol. 2013 Oct;1(2):152-62
pubmed: 24622321
AJR Am J Roentgenol. 2016 Nov;207(5):1046-1054
pubmed: 27556335
Nephrol Dial Transplant. 2014 Sep;29(9):1666-74
pubmed: 24286973
Semin Dial. 2011 Sep-Oct;24(5):487-94
pubmed: 21999737
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1820-6
pubmed: 25035342
Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):863-70
pubmed: 23349188
Nat Rev Nephrol. 2016 Dec;12(12):721-737
pubmed: 27748389
J Am Soc Nephrol. 2013 Nov;24(11):1727-36
pubmed: 24115475
Anal Chim Acta. 2016 Sep 14;936:149-56
pubmed: 27566350
Eur J Clin Nutr. 2018 Feb;72(2):288-296
pubmed: 29242526
Ann N Y Acad Sci. 2000 May;904:18-24
pubmed: 10865705
J Am Soc Nephrol. 2015 Oct;26(10):2521-33
pubmed: 25636412
Kidney Int. 2008 Aug;74(4):467-77
pubmed: 18496513
J Clin Endocrinol Metab. 2010 Dec;95(12):5419-26
pubmed: 20843952
J Appl Physiol (1985). 2000 Jul;89(1):104-10
pubmed: 10904041
Medicine (Baltimore). 2017 May;96(18):e6712
pubmed: 28471965
Health Econ. 2015 Jan;24(1):75-85
pubmed: 24123628