Post-treatment Lyme Disease as a Model for Persistent Symptoms in Lyme Disease.
Lyme disease
clinical presentation
post-treatment Lyme disease
research priorities
review
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
01
2020
accepted:
06
02
2020
entrez:
13
3
2020
pubmed:
13
3
2020
medline:
13
3
2020
Statut:
epublish
Résumé
It has long been observed in clinical practice that a subset of patients with Lyme disease report a constellation of symptoms such as fatigue, cognitive difficulties, and musculoskeletal pain, which may last for a significant period of time. These symptoms, which can range from mild to severe, have been reported throughout the literature in both prospective and population-based studies in Lyme disease endemic regions. The etiology of these symptoms is unknown, however several illness-causing mechanisms have been hypothesized, including microbial persistence, host immune dysregulation through inflammatory or secondary autoimmune pathways, or altered neural networks, as in central sensitization. Evaluation and characterization of persistent symptoms in Lyme disease is complicated by potential independent, repeat exposures to
Identifiants
pubmed: 32161761
doi: 10.3389/fmed.2020.00057
pmc: PMC7052487
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
57Informations de copyright
Copyright © 2020 Rebman and Aucott.
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