Brain metabolic alterations herald falls in patients with Parkinson's disease.
Accidental Falls
Aged
Cerebellum
/ diagnostic imaging
Female
Fluorodeoxyglucose F18
/ pharmacokinetics
Follow-Up Studies
Glucose
/ metabolism
Humans
Male
Middle Aged
Parietal Lobe
/ diagnostic imaging
Parkinson Disease
/ metabolism
Positron-Emission Tomography
Radiopharmaceuticals
/ pharmacokinetics
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
12
11
2019
revised:
12
02
2020
accepted:
19
02
2020
pubmed:
13
3
2020
medline:
20
4
2021
entrez:
13
3
2020
Statut:
ppublish
Résumé
Pathophysiological understanding of gait and balance disorders in Parkinson's disease is insufficient and late recognition of fall risk limits efficacious follow-up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6-8 months before their first fall episode. Falls in Parkinson's disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.
Identifiants
pubmed: 32162447
doi: 10.1002/acn3.51013
pmc: PMC7187714
doi:
Substances chimiques
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
579-583Informations de copyright
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
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