New actors in optic neuritis pathogenesis: An Editorial for "Influence of retinal NMDA receptor activity during autoimmune optic neuritis" on page 693.
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
11
02
2020
revised:
18
02
2020
accepted:
21
02
2020
pubmed:
13
3
2020
medline:
5
11
2020
entrez:
13
3
2020
Statut:
ppublish
Résumé
The aim of the present report was to analyze the involvement of glutamate neurotoxicity in retinal ganglion cell loss and optic nerve damage induced by experimental optic neuritis. For this purpose, the authors used an optic neuritis model induced by immunisation with myelin oligodendrocyte glycoprotein (AON). The authors describe a correlation in the timing of retinal ganglion cell (RGC) loss with alterations in the optic nerve actin cytoskeleton dynamic, and visual dysfunction. In addition, they show that an intravitreal injection of glutamate mimics, and an NMDA receptor antagonist avoids the effect of pre-clinical AON on visual functions and RGC number, as well as on optic nerve actin cytoskeleton. Taken together, their results support that avoiding glutamate neurotoxicity could become a new therapeutic approach for optic neuritis treatment.
Substances chimiques
Myelin-Oligodendrocyte Glycoprotein
0
Receptors, N-Methyl-D-Aspartate
0
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
671-673Informations de copyright
© 2020 International Society for Neurochemistry.
Références
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