Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?
Adult
Aged
Biopsy
Case-Control Studies
Claudin-1
/ genetics
Claudins
/ genetics
Colitis, Ulcerative
/ genetics
Cyclooxygenase 1
/ genetics
Cyclooxygenase 2
/ genetics
Female
Gene Expression Regulation
Gene Regulatory Networks
Humans
MARVEL Domain Containing 2 Protein
/ genetics
Male
Middle Aged
Young Adult
COX-1
COX-2
Inflammatory bowel disease
PGE2
mucosal barrier integrity
mucosal healing
short-circuit current
tight junction
ulcerative colitis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Mar 2020
10 Mar 2020
Historique:
received:
10
02
2020
revised:
03
03
2020
accepted:
05
03
2020
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Mucosal healing determined by endoscopy is currently the remission standard for ulcerative colitis (UC). However, new criteria for remission are emerging, such as histologic normalization, which appears to correlate better to the risk of relapse. Here, we study mucosal healing on a molecular and functional level in quiescent UC. We obtained endoscopic biopsies from 33 quiescent UC patients and from 17 controls. Histology was assessed using Geboes score. Protein and mRNA levels were evaluated for the tight junction proteins claudin-2, claudin-4, occludin, and tricellulin, as well as Cl
Identifiants
pubmed: 32164249
pii: ijms21051887
doi: 10.3390/ijms21051887
pmc: PMC7084207
pii:
doi:
Substances chimiques
CLDN1 protein, human
0
CLDN2 protein, human
0
Claudin-1
0
Claudins
0
MARVEL Domain Containing 2 Protein
0
MARVELD2 protein, human
0
Cyclooxygenase 1
EC 1.14.99.1
Cyclooxygenase 2
EC 1.14.99.1
PTGS1 protein, human
EC 1.14.99.1
PTGS2 protein, human
EC 1.14.99.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Familien Hede Nielsens Fond
ID : NA
Organisme : Grosserer LF Foghts Fond
ID : NA
Organisme : Else og Mogens Wedell Wedellsborgs Fond
ID : 22-17-1
Organisme : Candys Foundation
ID : 2016-179
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