Latest Insights into Marek's Disease Virus Pathogenesis and Tumorigenesis.
Marek’s disease virus
avian cancer
cell tropism
herpesvirus
life cycle
lymphoma
vaccine
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
10 Mar 2020
10 Mar 2020
Historique:
received:
22
02
2020
revised:
06
03
2020
accepted:
07
03
2020
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
14
3
2020
Statut:
epublish
Résumé
Marek's disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines against MDV were the first that prevented cancer and minimized the losses in the poultry industry. Even though the current gold standard vaccine efficiently protects against clinical disease, the virus continuously evolves towards higher virulence. Emerging field strains were able to overcome the protection provided by the previous two vaccine generations. Research over the last few years revealed important insights into the virus life cycle, cellular tropism, and tumor development that are summarized in this review. In addition, we discuss recent data on the MDV transcriptome, the constant evolution of this highly oncogenic virus towards higher virulence, and future perspectives in MDV research.
Identifiants
pubmed: 32164311
pii: cancers12030647
doi: 10.3390/cancers12030647
pmc: PMC7139298
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Volkswagen Foundation
ID : A112662
Organisme : China Scholarship Council
ID : Yu You
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