Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma.

Alphapapillomavirus / pathogenicity Alternative Splicing Carcinoma, Squamous Cell / genetics Cell Line, Tumor Chromatin Assembly and Disassembly Epigenesis, Genetic Gene Expression Regulation, Neoplastic Genetic Loci Histone Code Histones / chemistry Humans Oropharyngeal Neoplasms / genetics
Human papillomavirus alternative splicing oropharyngeal cancer super-enhancers

Journal

Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293

Informations de publication

Date de publication:
09 2020
Historique:
pubmed: 14 3 2020
medline: 3 6 2021
entrez: 14 3 2020
Statut: ppublish

Résumé

Human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) represents a unique disease entity within head and neck cancer with rising incidence. Previous work has shown that alternative splicing events (ASEs) are prevalent in HPV+ OPSCC, but further validation is needed to understand the regulation of this process and its role in these tumours. In this study, eleven ASEs (

Identifiants

DOI: 10.1080/15592294.2020.1741757 PMID: 32164487 PMC: PMC7518675
pubmed: 32164487
doi: 10.1080/15592294.2020.1741757
pmc: PMC7518675
doi:

Substances chimiques

Histones 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

959-971

Subventions

Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA243627
Pays : United States
Organisme : NIDCR NIH HHS
ID : P50 DE019032
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE027809
Pays : United States
Organisme : NIDCD NIH HHS
ID : T32 DC000027
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE025398
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177669
Pays : United States

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Auteurs

Theresa Guo (T)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
ORCID: 0000-0002-1689-3275

Kristina Diana A Zambo (KDA)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Fernando T Zamuner (FT)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Tingting Ou (T)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Christopher Hopkins (C)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Dylan Z Kelley (DZ)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Hildegard A Wulf (HA)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Eli Winkler (E)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Rossin Erbe (R)

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Ludmila Danilova (L)

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Laboratory of Systems Biology and Computational Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences , Moscow, Russia.
ORCID: 0000-0003-2813-3094

Michael Considine (M)

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

David Sidransky (D)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

Alexander Favorov (A)

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Laboratory of Systems Biology and Computational Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences , Moscow, Russia.
ORCID: 0000-0003-2595-1091

Liliana Florea (L)

McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University , Baltimore, MD, USA.
ORCID: 0000-0001-8124-2324

Elana J Fertig (EJ)

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Department of Applied Mathematics and Statistics, Johns Hopkins University , Baltimore, MD, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine , MD, Baltimore, USA.
ORCID: 0000-0003-3204-342X

Daria A Gaykalova (DA)

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
ORCID: 0000-0001-5037-0147

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Classifications MeSH

questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Papillomaviridae › Alphapapillomavirus › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Épissage alternatif › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Code histone › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chromatin structure regulates cancer-specific...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies du pharynx › Tumeurs du pharynx › Tumeurs de l'oropharynx › Chromatin structure regulates cancer-specific...