The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion.
Biomarkers
Immunity
Inflammation
Multivariate statistics
mTBI
Journal
BMC immunology
ISSN: 1471-2172
Titre abrégé: BMC Immunol
Pays: England
ID NLM: 100966980
Informations de publication
Date de publication:
12 03 2020
12 03 2020
Historique:
received:
31
10
2019
accepted:
26
02
2020
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Inflammation appears to be an important component of concussion pathophysiology. However, its relationship to symptom burden is unclear. Therefore, the purpose of this study was to evaluate the relationship between symptoms and inflammatory biomarkers measured in the blood of male and female athletes following a sport-related concussion (SRC). Forty athletes (n = 20 male, n = 20 female) from nine interuniversity sport teams at a single institution provided blood samples within one week of an SRC. Twenty inflammatory biomarkers were quantitated by immunoassay. The Sport Concussion Assessment Tool version 5 (SCAT-5) was used to evaluate symptoms. Partial least squares (PLS) analyses were used to evaluate the relationship(s) between biomarkers and symptoms. In males, a positive correlation between interferon (IFN)-γ and symptom severity was observed following SRC. The relationship between IFN-γ and symptoms was significant among all symptom clusters, with cognitive symptoms displaying the largest effect. In females, a significant negative relationship was observed between symptom severity and cytokines IFN-γ, tumor necrosis factor (TNF)-α, and myeloperoxidase (MPO); a positive relationship was observed between symptom severity and MCP-4. Inflammatory mediators were significantly associated with all symptom clusters in females; the somatic symptom cluster displayed the largest effect. These results provide supportive evidence of a divergent relationship between inflammation and symptom burden in male and female athletes following SRC. Future investigations should be cognizant of the potentially sex-specific pathophysiology underlying symptom presentation.
Sections du résumé
BACKGROUND
Inflammation appears to be an important component of concussion pathophysiology. However, its relationship to symptom burden is unclear. Therefore, the purpose of this study was to evaluate the relationship between symptoms and inflammatory biomarkers measured in the blood of male and female athletes following a sport-related concussion (SRC).
RESULTS
Forty athletes (n = 20 male, n = 20 female) from nine interuniversity sport teams at a single institution provided blood samples within one week of an SRC. Twenty inflammatory biomarkers were quantitated by immunoassay. The Sport Concussion Assessment Tool version 5 (SCAT-5) was used to evaluate symptoms. Partial least squares (PLS) analyses were used to evaluate the relationship(s) between biomarkers and symptoms. In males, a positive correlation between interferon (IFN)-γ and symptom severity was observed following SRC. The relationship between IFN-γ and symptoms was significant among all symptom clusters, with cognitive symptoms displaying the largest effect. In females, a significant negative relationship was observed between symptom severity and cytokines IFN-γ, tumor necrosis factor (TNF)-α, and myeloperoxidase (MPO); a positive relationship was observed between symptom severity and MCP-4. Inflammatory mediators were significantly associated with all symptom clusters in females; the somatic symptom cluster displayed the largest effect.
CONCLUSION
These results provide supportive evidence of a divergent relationship between inflammation and symptom burden in male and female athletes following SRC. Future investigations should be cognizant of the potentially sex-specific pathophysiology underlying symptom presentation.
Identifiants
pubmed: 32164571
doi: 10.1186/s12865-020-0339-3
pii: 10.1186/s12865-020-0339-3
pmc: PMC7068899
doi:
Substances chimiques
Biomarkers
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Peroxidase
EC 1.11.1.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11Références
Sleep Sci. 2015 Nov;8(3):143-52
pubmed: 26779321
Brain Behav Immun. 2014 May;38:111-7
pubmed: 24456846
Immunol Rev. 2012 Jul;248(1):228-39
pubmed: 22725965
J Cereb Blood Flow Metab. 2010 Mar;30(3):459-73
pubmed: 19904283
Pharmacol Rev. 2000 Dec;52(4):595-638
pubmed: 11121511
Sci Rep. 2017 Aug 24;7(1):8297
pubmed: 28839132
J Neurotrauma. 2016 Sep 1;33(17):1576-85
pubmed: 27035221
Sports Med. 2015 Jul;45(7):1027-40
pubmed: 25971368
Nat Rev Immunol. 2008 Sep;8(9):737-44
pubmed: 18728636
Chest. 2000 Aug;118(2):503-8
pubmed: 10936147
Semin Pediatr Neurol. 2019 Jul;30:14-25
pubmed: 31235015
J Head Trauma Rehabil. 2013 Sep-Oct;28(5):390-6
pubmed: 22613945
Handb Clin Neurol. 2018;158:51-61
pubmed: 30482375
Acta Biol Hung. 2002;53(1-2):229-44
pubmed: 12064774
J Neurol Neurosurg Psychiatry. 2008 Mar;79(3):300-6
pubmed: 17702772
J Head Trauma Rehabil. 2016 Jul-Aug;31(4):269-76
pubmed: 26479397
Annu Rev Immunol. 2002;20:125-63
pubmed: 11861600
J Cereb Blood Flow Metab. 2010 Apr;30(4):769-82
pubmed: 20029451
Br J Sports Med. 2006 Nov;40(11):923-7; discussion 927
pubmed: 16990442
Brain Behav Immun. 2007 May;21(4):384-92
pubmed: 17198749
Biol Psychiatry. 2009 Sep 1;66(5):415-22
pubmed: 19409533
Brain Inj. 2018;32(5):575-582
pubmed: 29420083
Nat Rev Immunol. 2006 Apr;6(4):318-28
pubmed: 16557263
Ann N Y Acad Sci. 2001 Mar;933:222-34
pubmed: 12000023
J Biol Chem. 1997 Jun 6;272(23):15036-42
pubmed: 9169480
Brain Behav Immun. 2015 May;46:1-16
pubmed: 25736063
Brain Behav Immun. 2016 Feb;52:18-26
pubmed: 26291403
Neuropsychopharmacology. 2019 Jan;44(1):45-58
pubmed: 30111811
Neurology. 2019 Nov 19;93(21):e1980-e1992
pubmed: 31619480
Neuropsychology. 2011 Jul;25(4):454-65
pubmed: 21574719
Trends Neurosci. 2002 Mar;25(3):154-9
pubmed: 11852148
Sci Rep. 2019 Dec 9;9(1):18605
pubmed: 31819094
Brain Sci. 2017 Aug 11;7(8):
pubmed: 28800081
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 4;64:277-84
pubmed: 26111720
J Neuroendocrinol. 2016 Jul;28(7):
pubmed: 27318180
Psychol Med. 2013 Jun;43(6):1127-32
pubmed: 22975198
Nat Rev Neurosci. 2017 Jun;18(6):375-384
pubmed: 28446786
Immunol Allergy Clin North Am. 2009 May;29(2):247-64
pubmed: 19389580
Autoimmun Rev. 2012 May;11(6-7):A486-92
pubmed: 22155200
Front Endocrinol (Lausanne). 2018 Apr 25;9:176
pubmed: 29922224
Br J Sports Med. 2013 Apr;47(5):289-93
pubmed: 23479486
Clin J Sport Med. 2012 Mar;22(2):98-104
pubmed: 22246342
Nat Rev Immunol. 2016 Oct;16(10):626-38
pubmed: 27546235
N Engl J Med. 1995 May 18;332(20):1351-62
pubmed: 7715646
Endocr Rev. 2015 Jun;36(3):305-42
pubmed: 25950715
Br J Sports Med. 2017 Jun;51(11):838-847
pubmed: 28446457
Cell Tissue Res. 2012 Jul;349(1):229-48
pubmed: 22700007
Ann N Y Acad Sci. 2012 Jul;1261:55-63
pubmed: 22823394
Biol Psychiatry. 2010 Mar 1;67(5):446-57
pubmed: 20015486
Arch Phys Med Rehabil. 2014 Mar;95(3 Suppl):S132-51
pubmed: 24581902
Pain Pract. 2018 Jan;18(1):8-17
pubmed: 28339138
Arch Gen Psychiatry. 2001 May;58(5):445-52
pubmed: 11343523
Neuroimage. 2011 May 15;56(2):455-75
pubmed: 20656037
Brain Behav Immun. 2001 Mar;15(1):7-24
pubmed: 11259077
Brain Behav Immun. 2009 Oct;23(7):877-84
pubmed: 19394418
J Neuroinflammation. 2019 Jan 26;16(1):17
pubmed: 30684956
Nat Rev Neurosci. 2008 Jan;9(1):46-56
pubmed: 18073775
Endocrinol Metab Clin North Am. 2015 Mar;44(1):151-9
pubmed: 25732651
Neurology. 2019 Jul 30;93(5):e497-e507
pubmed: 31270219
J Neuroinflammation. 2016 Feb 16;13:40
pubmed: 26883121
Scand J Clin Lab Invest. 2016;76(3):190-4
pubmed: 26963835
Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Dec;13(4):583-95
pubmed: 10903816
Front Neurol. 2018 Apr 12;9:239
pubmed: 29706930
Shock. 2016 Sep;46(3 Suppl 1):96-103
pubmed: 27206278
Cytokine. 2015 Dec;76(2):117-122
pubmed: 26315533
Neuroimage Clin. 2017 Jul 24;16:234-239
pubmed: 28794982
Acta Psychiatr Scand. 2017 May;135(5):373-387
pubmed: 28122130
Eur J Neurol. 2019 Dec;26(12):1426-1432
pubmed: 31002206