The potential role of central obesity in male infertility: body mass index versus waist to hip ratio as they relate to selected semen parameters.
Body mass index
Male infertility
Obesity
Statistical modelling
Waist to hip ratio
Journal
BMC public health
ISSN: 1471-2458
Titre abrégé: BMC Public Health
Pays: England
ID NLM: 100968562
Informations de publication
Date de publication:
12 Mar 2020
12 Mar 2020
Historique:
received:
10
08
2019
accepted:
26
02
2020
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
23
6
2020
Statut:
epublish
Résumé
Little is known about the potential role of central obesity among men. Our first aim was to confirm what is already known from prior research, namely that both BMI and WHR are inversely associated with selected semen parameters. Our second aim was to examine the potential role of central obesity by assessing if there was a difference between BMI and WHR regarding their relationships to these selected semen parameters. In this cross-sectional study between January 2011 to January 2018, we analyzed semen samples from 1169 patients who visited an andrology clinic in Budapest for infertility reasons. Variables assessed were: body measurements (height, weight, waist circumference, and hip circumference), and the results of semen analysis (sperm concentration, total sperm count, progressive sperm motility, and normal sperm morphology). The mean height and weight were 180.6 cm and 87.3 kg, respectively - the mean BMI was 26.8. The mean waist and hip circumferences were 100.9 cm and 94.8 cm, respectively - the mean waist to hip ratio was 0.94. The mean sperm concentration, total sperm count, and percents of progressive motility and normal morphology were 48.7 M/ml, 165 million, 21.2, and 4.8%, respectively. Both BMI and WHR were significant correlates in all semen parameter regression models. When comparing the parameter estimates for BMI with those for WHR for each semen parameter, the parameter estimate for WHR was significantly lower (indicating a stronger negative association) than that for BMI for progressive motility and total sperm count, but not for normal morphology or concentration. Our study is the first to examine, using a large patient sample, the potential role of central obesity by comparing the difference between BMI and WHR as they relate to selected semen parameters. Our findings indicate a potential role of central obesity for progressive motility and total sperm count, but not for normal morphology and concentration. Despite the limitations and the exploratory nature of this study, we can conclude that our results point to a potential role of central obesity in male infertility, but this finding should be confirmed and further explored in future research. The trial was retrospectively authorized after the data collection on September 24, 2018. Registration number: SE RKEB: 169/2018.
Sections du résumé
BACKGROUND
BACKGROUND
Little is known about the potential role of central obesity among men. Our first aim was to confirm what is already known from prior research, namely that both BMI and WHR are inversely associated with selected semen parameters. Our second aim was to examine the potential role of central obesity by assessing if there was a difference between BMI and WHR regarding their relationships to these selected semen parameters.
METHODS
METHODS
In this cross-sectional study between January 2011 to January 2018, we analyzed semen samples from 1169 patients who visited an andrology clinic in Budapest for infertility reasons. Variables assessed were: body measurements (height, weight, waist circumference, and hip circumference), and the results of semen analysis (sperm concentration, total sperm count, progressive sperm motility, and normal sperm morphology).
RESULTS
RESULTS
The mean height and weight were 180.6 cm and 87.3 kg, respectively - the mean BMI was 26.8. The mean waist and hip circumferences were 100.9 cm and 94.8 cm, respectively - the mean waist to hip ratio was 0.94. The mean sperm concentration, total sperm count, and percents of progressive motility and normal morphology were 48.7 M/ml, 165 million, 21.2, and 4.8%, respectively. Both BMI and WHR were significant correlates in all semen parameter regression models. When comparing the parameter estimates for BMI with those for WHR for each semen parameter, the parameter estimate for WHR was significantly lower (indicating a stronger negative association) than that for BMI for progressive motility and total sperm count, but not for normal morphology or concentration.
CONCLUSIONS
CONCLUSIONS
Our study is the first to examine, using a large patient sample, the potential role of central obesity by comparing the difference between BMI and WHR as they relate to selected semen parameters. Our findings indicate a potential role of central obesity for progressive motility and total sperm count, but not for normal morphology and concentration. Despite the limitations and the exploratory nature of this study, we can conclude that our results point to a potential role of central obesity in male infertility, but this finding should be confirmed and further explored in future research.
TRIAL REGISTRATION
BACKGROUND
The trial was retrospectively authorized after the data collection on September 24, 2018. Registration number: SE RKEB: 169/2018.
Identifiants
pubmed: 32164645
doi: 10.1186/s12889-020-8413-6
pii: 10.1186/s12889-020-8413-6
pmc: PMC7066798
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
307Subventions
Organisme : Semmelweis Egyetem
ID : EFOP-3.6.3-VEKOP-16-2017-00009
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