Predonation Single Kidney Glomerular Filtration Rate in Living Kidney Transplantation to Predict Graft Function and Donor Functional Gain.


Journal

Transplantation proceedings
ISSN: 1873-2623
Titre abrégé: Transplant Proc
Pays: United States
ID NLM: 0243532

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 06 11 2019
accepted: 10 01 2020
pubmed: 14 3 2020
medline: 10 9 2020
entrez: 14 3 2020
Statut: ppublish

Résumé

The 2 main objectives regarding living kidney transplant are to provide optimal graft function and to ensure the safety of donation. Our study hypothesized that the glomerular filtration rate of a single kidney (skGFR), when transplanted, might predict graft function and that the skGFR of the remaining kidney could predict donor functional gain. A prospective monocentric study was conducted at Grenoble-Alpes University Hospital. Twenty couples of donors and recipients were included. Dimercaptosuccinic acid renal scintigraphy and At 1 year post transplant, median glomerular filtration rate of the graft was 50 mL/min/1.73 m Predonation skGFR of the transplanted kidney had no influence on renal allograft function at 1 year post transplant. Similarly, there was no association between measured skGFR of the remaining kidney and donor functional gain at 1 year.

Sections du résumé

BACKGROUND BACKGROUND
The 2 main objectives regarding living kidney transplant are to provide optimal graft function and to ensure the safety of donation. Our study hypothesized that the glomerular filtration rate of a single kidney (skGFR), when transplanted, might predict graft function and that the skGFR of the remaining kidney could predict donor functional gain.
METHODS METHODS
A prospective monocentric study was conducted at Grenoble-Alpes University Hospital. Twenty couples of donors and recipients were included. Dimercaptosuccinic acid renal scintigraphy and
RESULTS RESULTS
At 1 year post transplant, median glomerular filtration rate of the graft was 50 mL/min/1.73 m
CONCLUSION CONCLUSIONS
Predonation skGFR of the transplanted kidney had no influence on renal allograft function at 1 year post transplant. Similarly, there was no association between measured skGFR of the remaining kidney and donor functional gain at 1 year.

Identifiants

pubmed: 32164958
pii: S0041-1345(19)31508-8
doi: 10.1016/j.transproceed.2020.01.026
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

712-721

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Morgane Heitz (M)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France.

Thomas Jouve (T)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France; Faculté de Médecine, Université Grenoble Alpes, Grenoble, France.

Matthieu Roustit (M)

Faculté de Médecine, Université Grenoble Alpes, Grenoble, France; Pôle Recherche, Inserm CIC1406, CHU Grenoble-Alpes, France.

Nicolas Terrier (N)

Service d'Urologie et Transplantation Rénale, CHU Grenoble-Alpes, France.

Gaëlle Fiard (G)

Faculté de Médecine, Université Grenoble Alpes, Grenoble, France; Service d'Urologie et Transplantation Rénale, CHU Grenoble-Alpes, France.

Stéphane Charara (S)

Clinique Universitaire de Radiologie et Imagerie Médicale, CHU Grenoble-Alpes, France.

Bénédicte Janbon (B)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France.

Johan Noble (J)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France; Faculté de Médecine, Université Grenoble Alpes, Grenoble, France.

Diane Giovannini (D)

Faculté de Médecine, Université Grenoble Alpes, Grenoble, France; Service d'anatomo-pathologie, CHU Grenoble-Alpes, France.

Hamza Naciri Bennani (HN)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France.

Isabelle Gomez (I)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France.

Paolo Malvezzi (P)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France.

Jean-Jacques Rambeaud (JJ)

Faculté de Médecine, Université Grenoble Alpes, Grenoble, France; Service d'Urologie et Transplantation Rénale, CHU Grenoble-Alpes, France.

Lionel Rostaing (L)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France; Faculté de Médecine, Université Grenoble Alpes, Grenoble, France. Electronic address: lrostaing@chu-grenoble.fr.

Rachel Tetaz (R)

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France.

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