High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies.
Animals
Brain
/ diagnostic imaging
Cerebral Ventricle Neoplasms
/ diagnostic imaging
Colonic Neoplasms
/ diagnostic imaging
Craniotomy
Diagnostic Imaging
/ methods
Disease Models, Animal
Endothelin-1
Epinephrine
Female
Heterografts
Image Processing, Computer-Assisted
/ methods
Imaging, Three-Dimensional
Lasers
Mice
Mice, Inbred BALB C
Neovascularization, Pathologic
/ diagnosis
Oxygen
Photoacoustic Techniques
/ methods
Ultrasonography
/ methods
Urinary Bladder Neoplasms
/ diagnostic imaging
Vascular Neoplasms
/ diagnostic imaging
Vasoconstriction
Journal
Nature biomedical engineering
ISSN: 2157-846X
Titre abrégé: Nat Biomed Eng
Pays: England
ID NLM: 101696896
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
10
12
2018
accepted:
06
02
2020
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
12
5
2020
Statut:
ppublish
Résumé
The monitoring of vascular-targeted therapies using magnetic resonance imaging, computed tomography or ultrasound is limited by their insufficient spatial resolution. Here, by taking advantage of the intrinsic optical properties of haemoglobin, we show that raster-scanning optoacoustic mesoscopy (RSOM) provides high-resolution images of the tumour vasculature and of the surrounding tissue, and that the detection of a wide range of ultrasound bandwidths enables the distinction of vessels of differing size, providing detailed insights into the vascular responses to vascular-targeted therapy. Using RSOM to examine the responses to vascular-targeted photodynamic therapy in mice with subcutaneous xenografts, we observed a substantial and immediate occlusion of the tumour vessels followed by haemorrhage within the tissue and the eventual collapse of the entire vasculature. Using dual-wavelength RSOM, which distinguishes oxyhaemoglobin from deoxyhaemoglobin, we observed an increase in oxygenation of the entire tumour volume immediately after the application of the therapy, and a second wave of oxygen reperfusion approximately 24 h thereafter. We also show that RSOM enables the quantification of differences in neoangiogenesis that predict treatment efficacy.
Identifiants
pubmed: 32165736
doi: 10.1038/s41551-020-0527-8
pii: 10.1038/s41551-020-0527-8
pmc: PMC7153756
mid: NIHMS1558084
doi:
Substances chimiques
Endothelin-1
0
Oxygen
S88TT14065
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
286-297Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA212379
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA183953
Pays : United States
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