Effect of Chronic Administration of Aqueous Leaves Extract of
Moringa stenopetala
biochemical parameters
chronic toxicity
hematological parameters
histology of kidney
histology of liver
rats
Journal
Ethiopian journal of health sciences
ISSN: 2413-7170
Titre abrégé: Ethiop J Health Sci
Pays: Ethiopia
ID NLM: 101224773
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Moringa stenopetala is used as nourishments, and treatment of various diseases. However, there is no much information on its safety. Hence, this study aimed to investigate the chronic administration of aqueous leaves extract of the plant. Twenty-four rats were divided into: a control group administered with distilled water and three experimental groups, respectively, administered with the extract at doses of 500, 1000, and 2000 mg/kg orally for six months were investigated. Various hematological and biochemical parameters followed by histopathological analysis were evaluated. Treatment with the extract did not significantly affect most of the hematological parameters. However, there were a significant decrease of MCH at doses of 1000 mg/kg and 2000 mg/kg in male rats and increase of MCV at all doses in female rats. Levels of ALP at 2000 mg/kg and those of AST and ALT at 1000 and 2000 mg/kg were significantly increased in male rats. Furthermore, significant decrease in urea and increase in creatinine levels at the dose of 2000 mg/kg occurred in female rats. Mild histopathological changes were also observed in the liver of male rats and kidney of female rats treated with the extract, respectively at doses of 1000 and 2000 mg/kg, and 2000 mg/kg. Findings from the present study suggest that prolonged administration of extract of Moringa stenopetala at therapeutic doses is safe, but shows sign of mild toxicity as dose increases, with differential effect on male verses female rats.
Sections du résumé
BACKGROUND
BACKGROUND
Moringa stenopetala is used as nourishments, and treatment of various diseases. However, there is no much information on its safety. Hence, this study aimed to investigate the chronic administration of aqueous leaves extract of the plant.
MATERIALS AND METHODS
METHODS
Twenty-four rats were divided into: a control group administered with distilled water and three experimental groups, respectively, administered with the extract at doses of 500, 1000, and 2000 mg/kg orally for six months were investigated. Various hematological and biochemical parameters followed by histopathological analysis were evaluated.
RESULTS
RESULTS
Treatment with the extract did not significantly affect most of the hematological parameters. However, there were a significant decrease of MCH at doses of 1000 mg/kg and 2000 mg/kg in male rats and increase of MCV at all doses in female rats. Levels of ALP at 2000 mg/kg and those of AST and ALT at 1000 and 2000 mg/kg were significantly increased in male rats. Furthermore, significant decrease in urea and increase in creatinine levels at the dose of 2000 mg/kg occurred in female rats. Mild histopathological changes were also observed in the liver of male rats and kidney of female rats treated with the extract, respectively at doses of 1000 and 2000 mg/kg, and 2000 mg/kg.
CONCLUSION
CONCLUSIONS
Findings from the present study suggest that prolonged administration of extract of Moringa stenopetala at therapeutic doses is safe, but shows sign of mild toxicity as dose increases, with differential effect on male verses female rats.
Identifiants
pubmed: 32165816
doi: 10.4314/ejhs.v30i2.14
pii: jEJHS.v30.i2.pg259
pmc: PMC7060390
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
259-268Informations de copyright
© 2020 Fikre Bayu, et al.
Références
J Ethnopharmacol. 2012 Jan 6;139(1):265-72
pubmed: 22101359
Toxicol Pathol. 2007 Aug;35(5):751-5
pubmed: 17849358
Arch Toxicol. 1988 Apr;61(5):344-8
pubmed: 3395245
PLoS Biol. 2010 Jun 29;8(6):e1000412
pubmed: 20613859
East Afr Med J. 2003 May;80(5):247-52
pubmed: 16167740
Phytother Res. 2007 Jan;21(1):17-25
pubmed: 17089328
Drug Metab Dispos. 1989 Jul-Aug;17(4):387-92
pubmed: 2571477
Afr Health Sci. 2012 Dec;12(4):545-51
pubmed: 23515422