Vitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators.
Neonates
Pentraxin 3
Pneumonia
Vitamin D
Journal
Open access Macedonian journal of medical sciences
ISSN: 1857-9655
Titre abrégé: Open Access Maced J Med Sci
Pays: North Macedonia
ID NLM: 101662294
Informations de publication
Date de publication:
15 Dec 2019
15 Dec 2019
Historique:
received:
05
11
2019
revised:
03
12
2019
accepted:
04
12
2019
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
14
3
2020
Statut:
epublish
Résumé
The study aimed to evaluate serum vitamin D concentrations among neonates with pneumonia. This case-control study enrolled 33 neonates with pneumonia in addition to 30 healthy controls. CBC, CRP, Serum vitamin D and Pentraxin 3 levels were measured for all participants. There was significant difference between patients and controls regarding Hemoglobin levels, TLC and CRP (p value < 0.01, = 0.002, < 0.01 respectively). Patients with pneumonia showed significant lower levels of Vit. D (9 ± 2.1) compared to controls (14.1 ± 2.8), P value < 0.01. However, patient group had significant higher levels of Pentraxin 3 (29.1 ± 4.8) compared with controls (12.6 ± 3), P value < 0.01. Moreover, mechanically ventilated patients revealed significant lower vit D (7.7 ± 1.8) and higher pentraxin 3 (32.2 ± 2.6) compared to patients on free oxygen (9.1 ± 2.1, 26.4 ± 3.7 respectively), P value = 0.05, 0.02 respectively. Regarding hospital stay, it had significant positive correlation with serum pentraxin 3 (r = 0.6, P value < 0.01) and significant negative correlation with serum vit D (r = -0.4, P value = 0.04). Finally a significant negative correlation between serum levels of vitamin D and Pentraxin 3 was found (r = -0.4, P value = 0.01). Lower concentration of serum vitamin D may be significantly associated with neonatal pneumonia. It also can predict the need for mechanical ventilation and duration of hospital stay in neonatal pneumonia. Similarly, higher levels of Pentraxin 3 may be used as an indicator for mechanical ventilation need and a longer hospital stay in neonates with pneumonia.
Identifiants
pubmed: 32165938
doi: 10.3889/oamjms.2019.592
pii: OAMJMS-7-3970
pmc: PMC7061372
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3970-3974Informations de copyright
Copyright: © 2019 Ghada M. El-Kassas, Maged A. El Wakeel, Mona A. Elabd, Alyaa H. Kamhawy, Mohamed Abdel Atti, Shereen A. Abd El-Gaffar, Salwa Kamal Hanafy, Eman Awadallah.
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