Low-Grade Malignancy Glomus Tumor in a Setting of Multiple Glomus Tumors - Case Report.
Breast
Cardiac
Glomus tumor
Intramuscular
Kidney
Low grade malignancy
Multiple localization
Journal
Open access Macedonian journal of medical sciences
ISSN: 1857-9655
Titre abrégé: Open Access Maced J Med Sci
Pays: North Macedonia
ID NLM: 101662294
Informations de publication
Date de publication:
15 Dec 2019
15 Dec 2019
Historique:
received:
12
06
2019
revised:
15
08
2019
accepted:
16
12
2019
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
14
3
2020
Statut:
epublish
Résumé
Glomus tumors are rare neoplasms accounting for less than 2% of all soft tissue tumors but multiple lesions may be seen in up to 10% of the patients. Solitary glomus tumor (GT) most frequently appears as small nodule in specific locations such as subungual region or deep dermis. However, rarely these entities have been observed in extracutaneous locations such as the gastrointestinal, cardiovascular, respiratory tracts, and other visceral organs. A small fraction of the GTs may present as tumors of uncertain malignant potential or as malignant glomus tumors. We report a patient with multiple glomus tumors on the time of diagnosis, which was histologically diagnosed as an atypical glomus tumor following resection of a tumor thrombus in the left renal vein, inferior vena cava trombus with intracardial extension, and mitral valve specimen. The intramuscular lesion from the thigh was diagnosed as a glomus tumor of uncertain malignant potential. Further examinations revealed multiple lesions trough her body: kidneys, breast, heart and subcutaneous tissue. The diagnosis of glomus tumor of uncertain malignant potential versus glomus tumor with low malignant potential could be quite challenging, and the clinical course may be as a determining factor for final diagnosis. To our knowledge, this is the only known case of glomus tumor with multiple organ involvement and aggressive biological behavior at presentation.
Sections du résumé
BACKGROUND
BACKGROUND
Glomus tumors are rare neoplasms accounting for less than 2% of all soft tissue tumors but multiple lesions may be seen in up to 10% of the patients. Solitary glomus tumor (GT) most frequently appears as small nodule in specific locations such as subungual region or deep dermis. However, rarely these entities have been observed in extracutaneous locations such as the gastrointestinal, cardiovascular, respiratory tracts, and other visceral organs. A small fraction of the GTs may present as tumors of uncertain malignant potential or as malignant glomus tumors.
CASE PRESENTATION
METHODS
We report a patient with multiple glomus tumors on the time of diagnosis, which was histologically diagnosed as an atypical glomus tumor following resection of a tumor thrombus in the left renal vein, inferior vena cava trombus with intracardial extension, and mitral valve specimen. The intramuscular lesion from the thigh was diagnosed as a glomus tumor of uncertain malignant potential. Further examinations revealed multiple lesions trough her body: kidneys, breast, heart and subcutaneous tissue. The diagnosis of glomus tumor of uncertain malignant potential versus glomus tumor with low malignant potential could be quite challenging, and the clinical course may be as a determining factor for final diagnosis.
CONCLUSION
CONCLUSIONS
To our knowledge, this is the only known case of glomus tumor with multiple organ involvement and aggressive biological behavior at presentation.
Identifiants
pubmed: 32165957
doi: 10.3889/oamjms.2019.610
pii: OAMJMS-7-4082
pmc: PMC7061405
doi:
Types de publication
Case Reports
Langues
eng
Pagination
4082-4088Informations de copyright
Copyright: © 2019 Violeta Vasilevska-Nikodinovska, Milan Samardjiski, Rubens Jovanovik, Boro Ilievski, Vesna Janevska.
Références
J Shoulder Elbow Surg. 2009 Jan-Feb;18(1):e1-3
pubmed: 18430592
Am J Surg Pathol. 2002 Mar;26(3):301-11
pubmed: 11859201
Hum Pathol. 2005 Mar;36(3):299-302
pubmed: 15791575
Radiology. 2007 Aug;244(2):494-504
pubmed: 17641370
Am J Surg Pathol. 2007 Apr;31(4):585-91
pubmed: 17414106
Arch Plast Surg. 2013 Jul;40(4):392-6
pubmed: 23898437
World J Surg Oncol. 2015 Feb 07;13:22
pubmed: 25888833
Int J Cardiol. 2012 Oct 18;160(3):e38-9
pubmed: 22360950
J Craniofac Surg. 2004 May;15(3):497-505
pubmed: 15111818
Actas Dermosifiliogr. 2009 Dec;100(10):875-82
pubmed: 20038364
Semin Roentgenol. 2010 Oct;45(4):277-97
pubmed: 20727455
Am J Surg Pathol. 2001 Jan;25(1):1-12
pubmed: 11145243
ANZ J Surg. 2018 Jun;88(6):653-654
pubmed: 26990249
Laryngoscope. 1999 Jan;109(1):30-4
pubmed: 9917036
Skeletal Radiol. 2011 Jul;40(7):855-62
pubmed: 21104079
J Med Ultrason (2001). 2014 Jul;41(3):385-8
pubmed: 27277916
Pediatr Blood Cancer. 2018 Jan;65(1):
pubmed: 28748602
Curr Mol Pharmacol. 2012 Jan;5(1):102-14
pubmed: 22122467
Onco Targets Ther. 2015 Jul 28;8:1909-14
pubmed: 26251614
Int J Surg Pathol. 2011 Jun;19(3):393-7
pubmed: 19164408
Thorac Cardiovasc Surg. 2012 Jun;60(4):305-6
pubmed: 21452115
Acta Orthop Traumatol Turc. 2016;50(2):242-4
pubmed: 26969962
Skeletal Radiol. 2005 Feb;34(2):108-11
pubmed: 15372213
Acta Orthop Traumatol Turc. 2003;37(3):244-8
pubmed: 12845297
J Foot Ankle Surg. 2008 Sep-Oct;47(5):483-6
pubmed: 18725132
Langenbecks Arch Surg. 2009 Mar;394(2):399-400
pubmed: 18446361
Hum Pathol. 2011 Aug;42(8):1200-3
pubmed: 21333326
N Engl J Med. 2003 Feb 20;348(8):694-701
pubmed: 12594313
Foot Ankle Surg. 2012 Jun;18(2):89-93
pubmed: 22443993
Radiol Clin North Am. 2011 Nov;49(6):1197-217, vi
pubmed: 22024295
Chir Main. 2000 Sep;19(4):243-52
pubmed: 11079182
Oncol Lett. 2013 Oct;6(4):1021-1024
pubmed: 24137457
JBR-BTR. 2010 Nov-Dec;93(6):292-5
pubmed: 21381525
DNA Repair (Amst). 2007 Aug 1;6(8):1155-60
pubmed: 17482895
Skull Base. 2002 May;12(2):53-8
pubmed: 17167644
Radiology. 2014 Jan;270(1):302-6
pubmed: 24354380
Hum Pathol. 2010 Jan;41(1):145-9
pubmed: 19896698
Cancer. 2003 Nov 1;98(9):1942-6
pubmed: 14584078
Dermatol Surg. 2008 Jul;34(7):884-90
pubmed: 18363721
Ann Plast Surg. 1999 Oct;43(4):436-8
pubmed: 10517474
J Postgrad Med. 2010 Jul-Sep;56(3):218-9
pubmed: 20739772
Plast Reconstr Surg. 2013 Dec;132(6):1087e-8e
pubmed: 24281631
Ann Pathol. 2015 Oct;35(5):440-4
pubmed: 26383552
Am J Surg Pathol. 2000 Aug;24(8):1105-14
pubmed: 10935651
Arch Pathol Lab Med. 2005 Sep;129(9):1172-4
pubmed: 16119994
Clin Genitourin Cancer. 2017 Feb;15(1):e151-e153
pubmed: 27349133
Mayo Clin Proc. 2006 Oct;81(10):1337-44
pubmed: 17036559
Acta Orthop Traumatol Turc. 2010;44(3):250-3
pubmed: 21088468