High-throughput analysis of DNA repair in microplates towards identification of inhibitors.
Base excision repair
DNA repair
High-throughput analysis
Journal
Genes and environment : the official journal of the Japanese Environmental Mutagen Society
ISSN: 1880-7046
Titre abrégé: Genes Environ
Pays: England
ID NLM: 101285347
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
11
2019
accepted:
05
02
2020
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
14
3
2020
Statut:
epublish
Résumé
Environmental factors can inhibit DNA repair and cause indirect mutagenic actions. Here the author introduces a recent paper on a novel high-throughput system to analyze the various enzymatic activities involved in base excision repair. Such systems will facilitate the identification of compounds that suppressively affect DNA repair.
Identifiants
pubmed: 32165992
doi: 10.1186/s41021-020-00153-3
pii: 153
pmc: PMC7061471
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe author declares that he has no competing interests.
Références
Genes Environ. 2016 Dec 1;39:2
pubmed: 27980700
Anal Chim Acta. 2019 Jul 4;1060:30-44
pubmed: 30902329
Annu Rev Genet. 2004;38:445-76
pubmed: 15568983
Chem Biol. 2014 Mar 20;21(3):398-407
pubmed: 24508195
Mutat Res. 2005 Apr 1;571(1-2):19-31
pubmed: 15748635
Genes Environ. 2018 Apr 4;40:5
pubmed: 29632621
Nucleic Acids Res. 2003 Jan 15;31(2):517-31
pubmed: 12527759
ACS Chem Biol. 2015 Oct 16;10(10):2334-43
pubmed: 26218629
Mutagenesis. 2002 Nov;17(6):483-7
pubmed: 12435845
J Am Chem Soc. 2018 Feb 14;140(6):2105-2114
pubmed: 29376367
Nucleic Acids Res. 2019 Jun 20;47(11):e61
pubmed: 30869144