SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism.
FAD
ROS
metabolism
mitochondria
transporter
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
25 Feb 2020
25 Feb 2020
Historique:
received:
12
08
2019
accepted:
16
12
2019
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
14
3
2020
Statut:
epublish
Résumé
SLC25A32 is a member of the solute carrier 25 family of mitochondrial transporters. SLC25A32 transports tetrahydrofolate (THF) as well as FAD into mitochondria and regulates mitochondrial one-carbon metabolism and redox balance. While it is known that cancer cells require one-carbon and FAD-dependent mitochondrial metabolism to sustain cell proliferation, the role of SLC25A32 in cancer cell growth remains unexplored. Our results indicate that the
Identifiants
pubmed: 32166001
doi: 10.18632/oncotarget.27486
pii: 27486
pmc: PMC7055544
doi:
Types de publication
Journal Article
Langues
eng
Pagination
801-812Informations de copyright
Copyright: © 2020 Santoro et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors have declared no conflicts of interest.
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