Effect of Sertoli Cell Transplantation on Reducing Neuroinflammation-Induced Necroptosis and Improving Motor Coordination in the Rat Model of Cerebellar Ataxia Induced by 3-Acetylpyridine.
Animals
Cells, Cultured
Cerebellar Ataxia
/ etiology
Glial Cell Line-Derived Neurotrophic Factor
/ genetics
Male
Movement
Necroptosis
PC12 Cells
Pyridines
/ toxicity
Rats
Rats, Sprague-Dawley
Rats, Wistar
Sertoli Cells
/ metabolism
Stem Cell Transplantation
/ methods
Vascular Endothelial Growth Factor A
/ genetics
Vimentin
/ genetics
Cell transplantation
Cerebellar ataxia
Neurodegeneration
Sertoli cells
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
09
11
2019
accepted:
28
02
2020
pubmed:
14
3
2020
medline:
22
1
2021
entrez:
14
3
2020
Statut:
ppublish
Résumé
To date, no certain cure has been found for patients with degenerative cerebellar disease. In this trial, we examined the in vivo and in vitro neuroprotective effects of Sertoli cells (SCs) on alleviating the symptoms of cerebellar ataxia. Testicular cells from an immature male rat were isolated and characterized by immunocytochemical analysis for somatic cell markers (anti-Mullerian hormone, vimentin). The protein assessment had already confirmed the expression of neurotrophic factors of glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial factor (VEGF). In vitro neuroprotective impact of SCs was determined after exposing PC12 cells to Sertoli cell-conditioned media (SC-CM) and H
Identifiants
pubmed: 32166479
doi: 10.1007/s12031-020-01522-x
pii: 10.1007/s12031-020-01522-x
doi:
Substances chimiques
Glial Cell Line-Derived Neurotrophic Factor
0
Pyridines
0
Vascular Endothelial Growth Factor A
0
Vimentin
0
3-acetylpyridine
00QT8FX306
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM