Clinical safety of low-dose anticoagulation with fondaparinux in patients undergoing peripheral endovascular treatment due to critical limb-threatening ischaemia - a pilot study.


Journal

Acta cardiologica
ISSN: 1784-973X
Titre abrégé: Acta Cardiol
Pays: England
ID NLM: 0370570

Informations de publication

Date de publication:
Jun 2021
Historique:
pubmed: 14 3 2020
medline: 6 11 2021
entrez: 14 3 2020
Statut: ppublish

Résumé

To evaluate the safety and effectiveness of fondaparinux in addition to dual antiplatelet therapy (DAPT) in patients with critical limb-threatening ischaemia (CLTI). Fondaparinux (2.5 mg/d) was administered for 1-4 weeks after endovascular procedures together with DAPT ( Twenty-four patients (78.7 ± 6.9 years, 14 [58%] female, 4 TASC B, 10 TASC C and 10 TASC D lesions, total lesion length = 210 ± 98 mm, mean Rutherford class = 4.7 ± 0.6) received fondaparinux (over a period of 22 ± 9 d, range 7-28 d) and DAPT Adding fondaparinux to DAPT does not seem to result in excess of clinically relevant bleeding. Our preliminary data suggest that prospective studies are now warranted in larger patient cohorts. DRKS00015856.

Identifiants

pubmed: 32167029
doi: 10.1080/00015385.2020.1737782
doi:

Substances chimiques

Anticoagulants 0
Platelet Aggregation Inhibitors 0
Fondaparinux J177FOW5JL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

365-372

Auteurs

Sorin Giusca (S)

Department of Cardiology, Vascular Medicine, Pneumology, Gastroenterology and Diabetology, GRN Hospital Weinheim, Weinheim, Germany.

Michael Lichtenberg (M)

Department of Angiology, Hospital Hochsauerland, Arnsberg, Germany.

Christoph Eisenbach (C)

Department of Cardiology, Vascular Medicine, Pneumology, Gastroenterology and Diabetology, GRN Hospital Weinheim, Weinheim, Germany.

Grigorios Korosoglou (G)

Department of Cardiology, Vascular Medicine, Pneumology, Gastroenterology and Diabetology, GRN Hospital Weinheim, Weinheim, Germany.

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Classifications MeSH