Dose response of black American mink to Aleutian mink disease virus.
Aleutian mink disease virus
American mink
anti-AMDV antibody
dose-response relationship
viremia
Journal
Immunity, inflammation and disease
ISSN: 2050-4527
Titre abrégé: Immun Inflamm Dis
Pays: England
ID NLM: 101635460
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
15
01
2020
accepted:
31
01
2020
pubmed:
14
3
2020
medline:
12
5
2021
entrez:
14
3
2020
Statut:
ppublish
Résumé
Aleutian mink disease virus (AMDV) causes a serious health problem for mink globally. The disease has no cure nor an effective vaccine and selection for tolerance using antibody titer is adopted by many mink farmers. The objective of this study was to investigate the effects of various doses of a local AMDV isolate on the response of black American mink to infection with AMDV. Eight black American mink were each inoculated intranasally with 0.5 mL of eight serial 10-fold dilutions (10 Antibody production persisted in all seroconverted mink until the termination of the experiment, whereas 71.1% of the mink showed short-lived viremia. Significant associations were observed between inoculum dose and the incidence of viremia until 84 dpi which disappeared thereafter, whereas associations between inoculum dose and the incidence of seropositive mink were significant on all sampling occasions. Antibody titer at 218 dpi significantly decreased with decreasing inoculum dose. AMDV DNA was detected in the bone marrow, lymph nodes, and spleen samples of almost all mink inoculated at every dose but was not detected in other organs of some mink. CIEP is more accurate than PCR for detecting AMDV infection in mink. Using antibody titer in naturally infected mink may not be accurate for the identification of tolerant mink.
Identifiants
pubmed: 32167659
doi: 10.1002/iid3.290
pmc: PMC7212202
doi:
Substances chimiques
Antibodies, Viral
0
DNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
150-164Informations de copyright
© 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
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