Plasma Concentrations of Extracellular DNA in Acute Kidney Injury.
cell free DNA
ischemia
nephrectomy
uremia
ureteral obstruction
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
11 Mar 2020
11 Mar 2020
Historique:
received:
21
01
2020
revised:
02
03
2020
accepted:
09
03
2020
entrez:
15
3
2020
pubmed:
15
3
2020
medline:
15
3
2020
Statut:
epublish
Résumé
Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma. A rapid turnover of ecDNA in the circulation makes it a potential marker with high sensitivity. This study aimed to analyze the concentration of ecDNA in plasma in animal models of AKI. Three different fractions of ecDNA were measured-total ecDNA was assessed fluorometrically, while nuclear ecDNA (ncDNA) and mitochondrial DNA (mtDNA) were analyzed using quantitative real-time PCR. AKI was induced using four different murine models of AKI-bilateral ureteral obstruction (BUO), glycerol-induced AKI (GLY), ischemia-reperfusion injury (IRI) and bilateral nephrectomy (BNx). Total ecDNA was significantly higher in BUO (
Identifiants
pubmed: 32168933
pii: diagnostics10030152
doi: 10.3390/diagnostics10030152
pmc: PMC7151483
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Slovak Research and Development Agency
ID : grant APVV-18-0278)
Organisme : European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement
ID : No. 842619-DIE_CKD
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