Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations.
Polymorphism
Skin pigmentation
UVB
Vitamin D
Journal
Genes & nutrition
ISSN: 1555-8932
Titre abrégé: Genes Nutr
Pays: Germany
ID NLM: 101280108
Informations de publication
Date de publication:
13 Mar 2020
13 Mar 2020
Historique:
received:
17
09
2019
accepted:
28
02
2020
entrez:
15
3
2020
pubmed:
15
3
2020
medline:
15
3
2020
Statut:
epublish
Résumé
The frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D status, UVB exposure and genetic disposition. Such interactions could have health implications, where UVB could modulate the impact of vitamin D genetic variants identified as disease risk factors. However, the current understanding of how vitamin D variants differ between populations from disparate UVB environments is limited, with previous work examining a small pool of variants and restricted populations only. Genotypic data for 46 variants within multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP27A1, CYP24A1, VDR, RXRα and RXRγ) was collated from 60 sample sets (2633 subjects) with European, East Asian and Sub-Saharan African origin via the NCBI 1000 Genomes Browser and ALFRED (Allele Frequency Database), with the aim to examine for patterns in the distribution of vitamin D-associated variants across these geographic areas. The frequency of all examined genetic variants differed between populations of European, East Asian and Sub-Saharan African ancestry. Changes in the distribution of variants in CYP2R1, CYP11A1, CYP24A1, RXRα and RXRγ genes between these populations are novel findings which have not been previously reported. The distribution of several variants reflected changes in the UVB environment of the population's ancestry. However, multiple variants displayed population-specific patterns in frequency that appears not to relate to UVB changes. The reported population differences in vitamin D-related variants provides insight into the extent by which activity of the vitamin D system can differ between cohorts due to genetic variance, with potential consequences for future dietary recommendations and disease outcomes.
Sections du résumé
BACKGROUND
BACKGROUND
The frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D status, UVB exposure and genetic disposition. Such interactions could have health implications, where UVB could modulate the impact of vitamin D genetic variants identified as disease risk factors. However, the current understanding of how vitamin D variants differ between populations from disparate UVB environments is limited, with previous work examining a small pool of variants and restricted populations only.
METHODS
METHODS
Genotypic data for 46 variants within multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP27A1, CYP24A1, VDR, RXRα and RXRγ) was collated from 60 sample sets (2633 subjects) with European, East Asian and Sub-Saharan African origin via the NCBI 1000 Genomes Browser and ALFRED (Allele Frequency Database), with the aim to examine for patterns in the distribution of vitamin D-associated variants across these geographic areas.
RESULTS
RESULTS
The frequency of all examined genetic variants differed between populations of European, East Asian and Sub-Saharan African ancestry. Changes in the distribution of variants in CYP2R1, CYP11A1, CYP24A1, RXRα and RXRγ genes between these populations are novel findings which have not been previously reported. The distribution of several variants reflected changes in the UVB environment of the population's ancestry. However, multiple variants displayed population-specific patterns in frequency that appears not to relate to UVB changes.
CONCLUSIONS
CONCLUSIONS
The reported population differences in vitamin D-related variants provides insight into the extent by which activity of the vitamin D system can differ between cohorts due to genetic variance, with potential consequences for future dietary recommendations and disease outcomes.
Identifiants
pubmed: 32169032
doi: 10.1186/s12263-020-00663-3
pii: 10.1186/s12263-020-00663-3
pmc: PMC7071568
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5Références
Am J Phys Anthropol. 2004 Nov;125(3):292-302
pubmed: 15386260
Calcif Tissue Int. 2005 Jul;77(1):15-22
pubmed: 15868280
Science. 2002 Apr 12;296(5566):261-2
pubmed: 11954565
Development. 1997 Dec;124(23):4749-58
pubmed: 9428411
BMJ. 2014 Apr 01;348:g2035
pubmed: 24690624
Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2:8962-8
pubmed: 20445093
Endocr J. 2012;59(11):1007-14
pubmed: 22785457
BMJ. 1995 Jan 21;310(6973):170
pubmed: 7833759
Am J Clin Nutr. 2014 Jun;99(6):1424-31
pubmed: 24740207
PLoS One. 2013;8(3):e58552
pubmed: 23505534
Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8052-7
pubmed: 26080414
Curr Opin Nephrol Hypertens. 2011 Jul;20(4):331-6
pubmed: 21654390
Ethn Dis. 2005 Autumn;15(4 Suppl 5):S5-97-101
pubmed: 16315387
J Steroid Biochem Mol Biol. 2015 Apr;148:72-8
pubmed: 25448743
Am J Clin Nutr. 2002 Jul;76(1):187-92
pubmed: 12081833
PLoS Genet. 2010 Mar 05;6(3):e1000867
pubmed: 20221248
BMC Evol Biol. 2013 Jul 09;13:144
pubmed: 23837623
Nutrients. 2018 Apr 30;10(5):
pubmed: 29710859
Lancet. 1982 Jan 9;1(8263):74-6
pubmed: 6119494
J Biochem. 2000 May;127(5):717-22
pubmed: 10788778
Nutr Rev. 2018 Jul 1;76(7):512-525
pubmed: 29718444
Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1339-43
pubmed: 18559548
Am J Phys Anthropol. 1985 Sep;68(1):107-22
pubmed: 4061596
Biochim Biophys Acta. 2012 Jan;1821(1):21-56
pubmed: 22020178
Dermatoendocrinol. 2013 Jan 1;5(1):51-108
pubmed: 24494042
Nucleic Acids Res. 2012 Jan;40(Database issue):D1010-5
pubmed: 22039151
Mol Biol Evol. 2013 Jan;30(1):24-35
pubmed: 22923467
Clin Chim Acta. 2006 Sep;371(1-2):1-12
pubmed: 16563362
G3 (Bethesda). 2016 May 03;6(5):1251-66
pubmed: 26921301
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
J Evid Based Complementary Altern Med. 2015 Oct;20(4):310-22
pubmed: 25878189
BMC Evol Biol. 2010 Nov 11;10:351
pubmed: 21070662
Hum Mol Genet. 2010 Jul 1;19(13):2739-45
pubmed: 20418485
J Hum Evol. 2000 Jul;39(1):57-106
pubmed: 10896812
Hum Genome Var. 2015 Dec 10;2:15058
pubmed: 27081560
Mol Biol Evol. 2007 Mar;24(3):710-22
pubmed: 17182896
Nat Commun. 2018 Jan 17;9(1):260
pubmed: 29343764
Lancet. 2010 Jul 17;376(9736):180-8
pubmed: 20541252
Chem Biol. 2014 Mar 20;21(3):319-29
pubmed: 24529992