Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.

Biomarkers, Tumor Colonic Neoplasms Colorectal Neoplasms Humans Neoplastic Stem Cells Receptors, G-Protein-Coupled
Lgr5 cancer stem cells circulating tumor cells colorectal cancer intravital microscopy metastasis microenvironment plasticity

Journal

Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472

Informations de publication

Date de publication:
02 04 2020
Historique:
received: 23 07 2019
revised: 24 12 2019
accepted: 13 02 2020
pubmed: 15 3 2020
medline: 28 4 2021
entrez: 15 3 2020
Statut: ppublish

Résumé

Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal cancer (CRC) and human tumor xenografts to investigate the cell of origin of metastases. We found that most disseminated CRC cells in circulation were Lgr5

Identifiants

DOI: 10.1016/j.stem.2020.02.008 PMID: 32169167 PMC: PMC7118369
pubmed: 32169167
pii: S1934-5909(20)30061-8
doi: 10.1016/j.stem.2020.02.008
pmc: PMC7118369
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
LGR5 protein, human 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

569-578.e7

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Arianna Fumagalli (A)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Koen C Oost (KC)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Molecular Cancer Research, Center for Molecular Medicine, Oncode Insitute, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.

Lennart Kester (L)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Jessica Morgner (J)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Laura Bornes (L)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Lotte Bruens (L)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Molecular Cancer Research, Center for Molecular Medicine, Oncode Insitute, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.

Lisa Spaargaren (L)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Maria Azkanaz (M)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Tim Schelfhorst (T)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Evelyne Beerling (E)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Maria C Heinz (MC)

Molecular Cancer Research, Center for Molecular Medicine, Oncode Insitute, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.

Daniel Postrach (D)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Danielle Seinstra (D)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Anieta M Sieuwerts (AM)

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD Rotterdam, the Netherlands.

John W M Martens (JWM)

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD Rotterdam, the Netherlands.

Stefan van der Elst (S)

Hubrecht Institute-KNAW & University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands.

Martijn van Baalen (M)

Flow Cytometry Facility, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Debajit Bhowmick (D)

Flow Cytometry Facility, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Nienke Vrisekoop (N)

Department of Respiratory Medicine, Center of Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, the Netherlands.

Saskia I J Ellenbroek (SIJ)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Saskia J E Suijkerbuijk (SJE)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Hugo J Snippert (HJ)

Molecular Cancer Research, Center for Molecular Medicine, Oncode Insitute, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.

Jacco van Rheenen (J)

Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address: j.v.rheenen@nki.nl.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Plasticity of Lgr5-Negative Cancer Cells...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Plasticity of Lgr5-Negative Cancer Cells...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Plasticity of Lgr5-Negative Cancer Cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Plasticity of Lgr5-Negative Cancer Cells...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › Plasticity of Lgr5-Negative Cancer Cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Plasticity of Lgr5-Negative Cancer Cells...