Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking.
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
20 05 2020
20 05 2020
Historique:
received:
05
11
2018
revised:
19
04
2019
accepted:
11
02
2020
pubmed:
15
3
2020
medline:
22
8
2020
entrez:
15
3
2020
Statut:
ppublish
Résumé
The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for information processing in neural circuits. However, little is known about the spatial principles of E and I synaptic organization across the entire dendritic tree of mammalian neurons. We developed a new open-source reconstruction platform for mapping the size and spatial distribution of E and I synapses received by individual genetically-labeled layer 2/3 (L2/3) cortical pyramidal neurons (PNs) in vivo. We mapped over 90,000 E and I synapses across twelve L2/3 PNs and uncovered structured organization of E and I synapses across dendritic domains as well as within individual dendritic segments. Despite significant domain-specific variation in the absolute density of E and I synapses, their ratio is strikingly balanced locally across dendritic segments. Computational modeling indicates that this spatially precise E/I balance dampens dendritic voltage fluctuations and strongly impacts neuronal firing output.
Identifiants
pubmed: 32169170
pii: S0896-6273(20)30138-0
doi: 10.1016/j.neuron.2020.02.015
pmc: PMC7244395
mid: NIHMS1568776
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
566-578.e8Subventions
Organisme : NINDS NIH HHS
ID : F31 NS101820
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS067557
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS109753
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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