Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex.
GABAergic interneurons
cortical layers
parvalbumin
somatosensory cortex
somatostatin
whisking
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
04 05 2020
04 05 2020
Historique:
received:
24
06
2019
revised:
16
01
2020
accepted:
03
02
2020
pubmed:
15
3
2020
medline:
18
8
2021
entrez:
15
3
2020
Statut:
ppublish
Résumé
The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.
Identifiants
pubmed: 32169206
pii: S0960-9822(20)30177-9
doi: 10.1016/j.cub.2020.02.004
pmc: PMC7198976
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1589-1599.e10Subventions
Organisme : NINDS NIH HHS
ID : U01 NS090576
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS107464
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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