A receptor-binding radiopharmaceutical for imaging of traumatic brain injury in a rodent model: [

Animals Brain Injuries, Traumatic / diagnostic imaging Dextrans / metabolism Disease Models, Animal Male Mannans / metabolism Mice Radiopharmaceuticals / metabolism Technetium Tc 99m Pentetate / analogs & derivatives
Blood brain barrier Fluorescence imaging Microglial cells Tilmanocept Traumatic brain injury cd206

Journal

Nuclear medicine and biology
ISSN: 1872-9614
Titre abrégé: Nucl Med Biol
Pays: United States
ID NLM: 9304420

Informations de publication

Date de publication:
01 2021
Historique:
received: 08 01 2020
revised: 19 02 2020
accepted: 24 02 2020
pubmed: 15 3 2020
medline: 5 10 2021
entrez: 15 3 2020
Statut: ppublish

Résumé

Blood-brain barrier (BBB) disruption and subsequent neuro-inflammation occur following traumatic brain injury (TBI), resulting in a spectrum of human nervous system disorders. [ Age-matched mice were divided into three groups: 5-days post TBI (n = 4), and 5-days post sham (n = 4), and naïve controls (n = 4). IRDye800CW-labeled [ In vivo nuclear imaging, ex vivo fluorescence imaging, ex vivo gamma well counting, and histo-microscopy demonstrated enhanced tilmanocept uptake in the TBI region. The normalized [ [

Identifiants

DOI: 10.1016/j.nucmedbio.2020.02.013 PMID: 32169304
pubmed: 32169304
pii: S0969-8051(20)30003-2
doi: 10.1016/j.nucmedbio.2020.02.013
pii:
doi:

Substances chimiques

Dextrans 0
Mannans 0
Radiopharmaceuticals 0
technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran 0
Technetium Tc 99m Pentetate VW78417PU1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

107-114

Subventions

Organisme : NCI NIH HHS
ID : P50 CA128346
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest David Vera is the inventor of Tilmanocept. The remaining authors declare that they have no conflict of interest.

Auteurs

Wen Chen (W)

Department of Radiology, University of California, San Diego, La Jolla, CA, USA.

Christopher V Barback (CV)

Department of Radiology, University of California, San Diego, La Jolla, CA, USA.

Shanshan Wang (S)

Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA; Department of Anesthesiology, University of California, San Diego, La Jolla, USA.

Carl K Hoh (CK)

Department of Radiology, University of California, San Diego, La Jolla, CA, USA.

Eric Y Chang (EY)

Department of Radiology, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA.

David J Hall (DJ)

Department of Radiology, University of California, San Diego, La Jolla, CA, USA.

Brian P Head (BP)

Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA; Department of Anesthesiology, University of California, San Diego, La Jolla, USA.

David R Vera (DR)

Department of Radiology, University of California, San Diego, La Jolla, CA, USA. Electronic address: dvera@ucsd.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A receptor-binding radiopharmaceutical for...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › A receptor-binding radiopharmaceutical for...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › A receptor-binding radiopharmaceutical for...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A receptor-binding radiopharmaceutical for...
questionsmedicales.fr › Glucides › Polyosides › Mannanes › A receptor-binding radiopharmaceutical for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A receptor-binding radiopharmaceutical for...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › A receptor-binding radiopharmaceutical for...
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Composés organiques du technétium › Pentétate de technétium (99mTc) › A receptor-binding radiopharmaceutical for...