A systematic review of ultrasound imaging and therapy in mental disorders.
Depressive disorders
Flow-mediated dilatation
Intima-media thickness
Transcranial Doppler
Transcranial focused ultrasound
Transcranial sonography
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
13 07 2020
13 07 2020
Historique:
received:
01
11
2019
revised:
06
03
2020
accepted:
09
03
2020
pubmed:
15
3
2020
medline:
5
6
2021
entrez:
15
3
2020
Statut:
ppublish
Résumé
Increasing evidence suggests that ultrasound (US) imaging may provide biomarkers and therapeutic options in mental disorders. We systematically reviewed the literature to provide a global overview of the possibilities of US for psychiatry. Original English language articles published between January 2000 and September 2019 were identified through databases searching and analyzed to summarize existing evidence according to PRISMA methodology. A total of 81 articles were included. Various US techniques and markers have been used in mental disorders, including Transcranial Doppler and Intima-Media Thickness. Most of the studies have focused on characterizing the pathophysiology of mental disorders, especially vascular physiology. Studies on therapeutic applications are still scarce. US imaging has proved to be useful in characterizing vascular impairment and structural and functional brain changes in mental disorders. Preliminary findings also suggest potential interests for therapeutic applications. Growing evidence suggests that US imaging could provide a non-invasive, portable and low-cost tool for pathophysiological characterization, prognostic assessment and therapeutic applications in mental disorders.
Sections du résumé
BACKGROUND
Increasing evidence suggests that ultrasound (US) imaging may provide biomarkers and therapeutic options in mental disorders. We systematically reviewed the literature to provide a global overview of the possibilities of US for psychiatry.
METHODS
Original English language articles published between January 2000 and September 2019 were identified through databases searching and analyzed to summarize existing evidence according to PRISMA methodology.
RESULTS
A total of 81 articles were included. Various US techniques and markers have been used in mental disorders, including Transcranial Doppler and Intima-Media Thickness. Most of the studies have focused on characterizing the pathophysiology of mental disorders, especially vascular physiology. Studies on therapeutic applications are still scarce.
DISCUSSION
US imaging has proved to be useful in characterizing vascular impairment and structural and functional brain changes in mental disorders. Preliminary findings also suggest potential interests for therapeutic applications. Growing evidence suggests that US imaging could provide a non-invasive, portable and low-cost tool for pathophysiological characterization, prognostic assessment and therapeutic applications in mental disorders.
Identifiants
pubmed: 32169563
pii: S0278-5846(19)30918-2
doi: 10.1016/j.pnpbp.2020.109919
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109919Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest WEH reports personal fees from EISAI, Japan, Janssen, USA, Lundbeck, Denmark, Otsuka, Japan, UCB, Belgium, Roche, Switzerland and Chugai, Japan. He received grants from the Fondation de France, France, and from the French National Hospital Program for Clinical Research (PHRC), unrelated to the submitted work. TD reports personal fees from Janssen, Lundbeck, Otsuka and Eisai. He received grants from the Fondation de l'Avenir, France, and from the French National Hospital Program for Clinical Research (PHRC), France, unrelated to the submitted work. All other authors declare no competing interests.