IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 04 2020
15 04 2020
Historique:
received:
09
05
2019
accepted:
04
02
2020
pubmed:
15
3
2020
medline:
31
12
2020
entrez:
15
3
2020
Statut:
ppublish
Résumé
Emerging evidence suggests comprehensive immune profiling represents a highly promising, yet insufficiently tapped approach to identify potentially prognostic signatures for periodontitis. In this report, we agnostically identified a periodontitis-associated inflammatory expression network with multiple biomarkers identified within gingival crevicular fluid samples from study participants by applying principal component analysis. We identified an IL-17-dominated trait that is associated with periodontal disease and is inversely modified by the level of IL-10. IL-10 mitigated chemokine CXCL5 and CXCL1 expressions in IL-17-stimulated peripheral blood monocytic cells and peripheral blood monocytic cell-derived macrophages.
Identifiants
pubmed: 32169848
pii: jimmunol.1900532
doi: 10.4049/jimmunol.1900532
pmc: PMC7840149
mid: NIHMS1588922
doi:
Substances chimiques
IL10 protein, mouse
0
Interleukin-17
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2177-2191Subventions
Organisme : NIDCR NIH HHS
ID : R00 DE027086
Pays : United States
Organisme : NIDCR NIH HHS
ID : K99 DE027086
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE023836
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026728
Pays : United States
Organisme : NIDCR NIH HHS
ID : R00 DE024173
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE021418
Pays : United States
Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
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