Identification of

Adult Aged Aged, 80 and over Chemotherapy, Adjuvant DNA Polymerase II / genetics Decision Making Endometrial Neoplasms / genetics Female Humans Hysterectomy Immunohistochemistry Microsatellite Instability Middle Aged Mutation Neoplasm Staging Poly-ADP-Ribose Binding Proteins / genetics Prognosis Proportional Hazards Models Radiotherapy, Adjuvant Tumor Suppressor Protein p53 / genetics
endometrial neoplasms pathology

Journal

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
ISSN: 1525-1438
Titre abrégé: Int J Gynecol Cancer
Pays: England
ID NLM: 9111626

Informations de publication

Date de publication:
05 2020
Historique:
received: 10 09 2019
revised: 31 01 2020
accepted: 24 02 2020
pubmed: 15 3 2020
medline: 23 12 2020
entrez: 15 3 2020
Statut: ppublish

Résumé

Molecular classification of endometrial carcinoma has been proposed to predict survival. However, its role in patient management remains to be determined. We aimed to identify whether a molecular and immunohistochemical classification of endometrial carcinoma could improve decision-making for adjuvant therapy. All consecutive patients treated for endometrial carcinoma between 2010 and 2017 at Cochin University Hospital were included. Clinical risk of relapse was based on European Society for Medical Oncology-European Society of Gynaecological Oncology-European SocieTy for Radiotherapy & Oncology (ESMO-ESGO-ESTRO) consensus. The clinical event of interest was event-free survival. Formalin-fixed paraffin-embedded tissue samples were processed for histopathological analysis and DNA extraction. The nuclear expression of mismatch repair and TP53 proteins was analyzed by immunohistochemistry. Next-generation sequencing of a panel of 15 genes including 159 patients were included; 125 tumors were available for molecular characterization and distributed as follows: (1) Endometrial carcinoma molecular classification identified potentially under-treated patients with poor molecular prognosis despite being at low/intermediate clinical risk of relapse. Consideration of molecular classification in adjuvant therapeutic decisions should be evaluated in prospective trials.

Identifiants

DOI: 10.1136/ijgc-2019-000871 PMID: 32169874
pubmed: 32169874
pii: ijgc-2019-000871
doi: 10.1136/ijgc-2019-000871
doi:

Substances chimiques

Poly-ADP-Ribose Binding Proteins 0
TP53 protein, human 0
Tumor Suppressor Protein p53 0
DNA Polymerase II EC 2.7.7.7
POLE protein, human EC 2.7.7.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

640-647

Informations de copyright

© IGCS and ESGO 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Guillaume Beinse (G)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.

Bastien Rance (B)

Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Department of Medical Informatics, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

Pierre-Alexandre Just (PA)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.
Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Department of Pathological Anatomy and Cytology, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

Brigitte Izac (B)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.

Franck Letourneur (F)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.

Nathaniel Edward Bennett Saidu (NEB)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.

Sandrine Chouzenoux (S)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.

Carole Nicco (C)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.

François Goldwasser (F)

Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Department of Medical Oncology, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

Frederic Batteux (F)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.
Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.

Catherine Durdux (C)

Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Departement of Radiation Oncology, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

Charles Chapron (C)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.
Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Department of Gynecologic Surgery, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

Eric Pasmant (E)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.
Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Department of Genetics and Molecular Biology, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

Karen Leroy (K)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France.
Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Department of Genetics and Molecular Biology, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

Jerome Alexandre (J)

Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Department of Medical Oncology, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

Bruno Borghese (B)

U1016 Institut Cochin, INSERM, CARPEM, Paris, Île-de-France, France bruno.borghese@aphp.fr.
Université Paris Descartes, Sorbonne Paris Cité, Paris, Île-de-France, France.
Department of Gynecologic Surgery, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, Île-de-France, France.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Identification of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Identification of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Identification of
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitement médicamenteux adjuvant › Identification of
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › DNA nucleotidyltransferases › DNA-directed DNA polymerase › DNA polymerase II › Identification of
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Identification of
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital féminin › Tumeurs de l'utérus › Tumeurs de l'endomètre › Identification of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie gynécologique › Hystérectomie › Identification of
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Identification of
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des microsatellites › Identification of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Identification of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Identification of
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Identification of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Identification of
questionsmedicales.fr › Diagnostic › Pronostic › Identification of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Identification of
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie adjuvante › Identification of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Identification of