Imaging local genetic influences on cortical folding.
cerebral cortex
cortical folding
cortical thickness
genetic correlation
structural MRI
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
31 03 2020
31 03 2020
Historique:
pubmed:
15
3
2020
medline:
15
8
2020
entrez:
15
3
2020
Statut:
ppublish
Résumé
Recent progress in deciphering mechanisms of human brain cortical folding leave unexplained whether spatially patterned genetic influences contribute to this folding. High-resolution in vivo brain MRI can be used to estimate genetic correlations (covariability due to shared genetic factors) in interregional cortical thickness, and biomechanical studies predict an influence of cortical thickness on folding patterns. However, progress has been hampered because shared genetic influences related to folding patterns likely operate at a scale that is much more local (<1 cm) than that addressed in prior imaging studies. Here, we develop methodological approaches to examine local genetic influences on cortical thickness and apply these methods to two large, independent samples. We find that such influences are markedly heterogeneous in strength, and in some cortical areas are notably stronger in specific orientations relative to gyri or sulci. The overall, phenotypic local correlation has a significant basis in shared genetic factors and is highly symmetric between left and right cortical hemispheres. Furthermore, the degree of local cortical folding relates systematically with the strength of local correlations, which tends to be higher in gyral crests and lower in sulcal fundi. The relationship between folding and local correlations is stronger in primary sensorimotor areas and weaker in association areas such as prefrontal cortex, consistent with reduced genetic constraints on the structural topology of association cortex. Collectively, our results suggest that patterned genetic influences on cortical thickness, measurable at the scale of in vivo MRI, may be a causal factor in the development of cortical folding.
Identifiants
pubmed: 32170019
pii: 1912064117
doi: 10.1073/pnas.1912064117
pmc: PMC7132284
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7430-7436Subventions
Organisme : NIMH NIH HHS
ID : R01 MH112847
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : K08 MH120564
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH078111
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA MH002794
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086888
Pays : United States
Organisme : NIH HHS
ID : S10 OD023495
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH078143
Pays : United States
Organisme : NCRR NIH HHS
ID : C06 RR015456
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119219
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH059490
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058464
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH083824
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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