Lumbar spinal stenosis and disc alterations affect the upper lumbar spine in adults with achondroplasia.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 03 2020
13 03 2020
Historique:
received:
16
10
2019
accepted:
29
02
2020
entrez:
15
3
2020
pubmed:
15
3
2020
medline:
24
11
2020
Statut:
epublish
Résumé
In achondroplasia, lumbar spinal stenosis arises from congenital dysplasia and acquired degenerative changes. We here aimed to describe the changes of the lumbar spinal canal and intervertebral disc in adults. We included 18 adults (age ≥ 18 years) with achondroplasia and lumbar spinal stenosis. Radiographs were used to analyze spinal-pelvic angles. Antero-posterior diameter of the spinal canal and the grade of disc degeneration were measured by MRI. Antero-posterior diameters of the spinal canal differed by spinal level (P < 0.05), with lower values observed at T12-L1, L1-2 and L2-3. Degrees of disc degeneration differed by intervertebral level, with higher degrees observed at L1-2, L2-3 and L3-4. A significant correlation was found between disc degeneration and thoraco-lumbar kyphosis at L2-3, between antero-posterior diameter of the spinal canal and lumbar lordosis at T12-L1 and L2-3, and between antero-posterior diameter of the spinal canal and thoraco-lumbar kyphosis at L1-2. Unlike the general population, spinal stenosis and disc degeneration involve the upper part of the lumbar spine in adults with achondroplasia, associated with thoraco-lumbar kyphosis and loss of lumbar lordosis.
Identifiants
pubmed: 32170149
doi: 10.1038/s41598-020-61704-w
pii: 10.1038/s41598-020-61704-w
pmc: PMC7070089
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4699Références
Horton, W. A., Hall, J. G. & Hecht, J. T. Achondroplasia. Lancet 370, 162–72 (2007).
doi: 10.1016/S0140-6736(07)61090-3
Baujat, G., Legeai-Mallet, L., Finidori, G., Cormier-Daire, V. & Le Merrer, M. Achondroplasia. Best Pract Res Clin Rheumatol. 22, 3–18 (2008).
doi: 10.1016/j.berh.2007.12.008
Rousseau, F. et al. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature. 371, 252–4 (1994).
doi: 10.1038/371252a0
Shiang, R. et al. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell. 78, 335–42 (1994).
doi: 10.1016/0092-8674(94)90302-6
Mahomed, N. N., Spellmann, M. & Goldberg, M. J. Functional health status of adults with achondroplasia. Am J Med Genet. 78, 30–5 (1998).
doi: 10.1002/(SICI)1096-8628(19980616)78:1<30::AID-AJMG7>3.0.CO;2-P
Hunter, A. G., Bankier, A., Rogers, J. G., Sillence, D. & Scott, C. I. Jr. Medical complications of achondroplasia: a multicentre patient review. J Med Genet. 35, 705–12 (1998).
doi: 10.1136/jmg.35.9.705
Ain, M. C. et al. Progression of low back and lower extremity pain in a cohort of patients with achondroplasia. J Neurosurg Spine. 13, 335–40 (2010).
doi: 10.3171/2010.3.SPINE09629
Jeong, S. T. et al. MRI study of the lumbar spine in achondroplasia. A morphometric analysis for the evaluation of stenosis of the canal. J Bone Joint Surg Br. 88, 1192–6 (2006).
doi: 10.1302/0301-620X.88B9.17758
Matsushita, T. et al. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet. 18, 227–40 (2009).
doi: 10.1093/hmg/ddn339
Katz, J. N. & Harris, M. B. Clinical practice. Lumbar spinal stenosis N Engl J Med. 358, 818–25 (2008).
doi: 10.1056/NEJMcp0708097
Lee, S. Y., Kim, T. H., Oh, J. K., Lee, S. J. & Park, M. S. Lumbar Stenosis: A Recent Update by Review of Literature. Asian. Spine J. 9, 818–28 (2015).
Lurie, J. & Tomkins-Lane, C. Management of lumbar spinal stenosis. BMJ. 352, h6234 (2016).
doi: 10.1136/bmj.h6234
Modi, H. N., Suh, S. W., Song, H. R. & Yang, J. H. Lumbar nerve root occupancy in the foramen in achondroplasia: a morphometric analysis. Clin Orthop Relat Res. 466, 907–13 (2008).
doi: 10.1007/s11999-008-0142-6
Epstein, N. E., Maldonado, V. C. & Cusick, J. F. Symptomatic lumbar spinal stenosis. Surg Neurol. 50, 3–10 (1998).
doi: 10.1016/S0090-3019(98)00022-6
Srikumaran, U. et al. Pedicle and spinal canal parameters of the lower thoracic and lumbar vertebrae in the achondroplast population. Spine. 32, 2423–31 (2007).
doi: 10.1097/BRS.0b013e3181574286
Thomeer, R. T. & van Dijk, J. M. Surgical treatment of lumbar stenosis in achondroplasia. J Neurosurg. 96, 292–7 (2002).
pubmed: 11990837
Teraguchi, M. et al. Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study. Osteoarthritis Cartilage. 22, 104–10 (2014).
doi: 10.1016/j.joca.2013.10.019
like, M. et al. Solovieva S, Lamminen A, Luoma K, Leino-Arjas P, Luukkonen R, Riihimäki H (2005) Disc degeneration of the lumbar spine in relation to overweight. Int J Obes. 29, 903–8 (2005).
doi: 10.1038/sj.ijo.0802974
Samartzis, D., Karppinen, J., Chan, D., Luk, K. D. & Cheung, K. M. The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study. Arthritis Rheum. 64, 1488–96 (2012).
doi: 10.1002/art.33462
Roussouly, P. & Pinheiro-Franco, J. L. Biomechanical analysis of the spino-pelvic organization and adaptation in pathology. Eur Spine J. 20, 609–18 (2011).
doi: 10.1007/s00586-011-1928-x
Hong, J. Y., Suh, S. W., Modi, H. N., Park, J. W. & Park, J. H. Analysis of sagittal spinopelvic parameters in achondroplasia. Spine. 36, E1233–9 (2011).
doi: 10.1097/BRS.0b013e3182063e89
Kahanovitz, N., Rimoin, D. L. & Sillence, D. O. The clinical spectrum of lumbar spine disease in achondroplasia. Spine. 7, 137–40 (1982).
doi: 10.1097/00007632-198203000-00008
Pfirrmann, C. W., Metzdorf, A., Zanetti, M., Hodler, J. & Boos, N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 26, 1873–8 (2001).
doi: 10.1097/00007632-200109010-00011
Landis, J. R. & Koch, G. G. The measurement of observer agreement for categorical data. Biometrics. 33, 159–74 (1977).
doi: 10.2307/2529310