Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
23
01
2019
accepted:
07
01
2020
pubmed:
15
3
2020
medline:
17
9
2020
entrez:
15
3
2020
Statut:
ppublish
Résumé
This study aimed to test the hypothesis that young adults with obesity and cold-activated brown adipose tissue (BAT) are less likely to have metabolic dysfunction (dyslipidemia, insulin resistance, and hypertension) than those without cold-activated BAT. Previous studies have noted a potentially protective effect of BAT and higher adiponectin/leptin ratios, but they have acknowledged that the clinical implications of these findings remain uncertain. Twenty-one females and twenty-three males with obesity (BMI ≥ 30 kg/m Cold-activated BAT was identified in 43% of participants (11 female, 8 male); females had greater A high prevalence of cold-activated BAT was found in the study participants. BAT could be important in decreasing metabolic dysfunction among young adults with obesity, making it a potential target for treating metabolically unhealthy obesity.
Identifiants
pubmed: 32170839
doi: 10.1002/oby.22767
pmc: PMC7180112
mid: NIHMS1556339
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
916-923Subventions
Organisme : University of Utah
Pays : International
Organisme : NHLBI NIH HHS
ID : K23 HL092069
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002538
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR001067
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL#092069
Pays : United States
Organisme : Huntsman Cancer Institute
ID : 3
Pays : International
Organisme : NIH HHS
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001067
Pays : United States
Organisme : Huntsman Cancer Institute
ID : 5
Pays : International
Informations de copyright
© 2020 The Obesity Society.
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