Genetic determinants of telomere length and cancer risk.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
20
11
2019
revised:
28
01
2020
accepted:
03
02
2020
pubmed:
15
3
2020
medline:
11
5
2021
entrez:
15
3
2020
Statut:
ppublish
Résumé
The relationship of telomere length with cancer risk has been the source of much debate within epidemiological studies, which have produced inconsistent finding both between and within different cancer types. Over recent years, genome-wide association studies of increasing size have identified variants that determine human telomere length. These variants have subsequently been utilised as instrumental variables in Mendelian randomisation based studies, allowing the investigation of potential causal relationships between telomere length and cancer. Here we discuss recent advances in both genomic discovery, studies that give increasing evidence towards a causal role for telomere length in cancer risk and considerations for future studies.
Identifiants
pubmed: 32171108
pii: S0959-437X(20)30012-5
doi: 10.1016/j.gde.2020.02.007
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-68Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.