Sonographic and 3T-MRI-based evaluation of the tongue in ALS.
Amyotrophic lateral sclerosis
Biomarker
Intensity
MRI
Prognosis
Tongue
Ultrasound
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
11
2019
revised:
18
02
2020
accepted:
29
02
2020
pubmed:
15
3
2020
medline:
23
2
2021
entrez:
15
3
2020
Statut:
ppublish
Résumé
A few systematic imaging studies employing ultrasound (HRUS) and magnetic resonance imaging (MRI) have suggested tongue measures to aid in diagnosis of amyotrophic lateral sclerosis (ALS). The relationship between structural tongue alterations and the ALS patients' bulbar and overall motor function has not yet been elucidated. We here thus aimed to understand how in-vivo tongue alterations relate to motor function and motor function evolution over time in ALS. Our study included 206 ALS patients and 104 age- and sex-matched controls that underwent HRUS and 3T MRI of the tongue at baseline. Sonographic measures comprised coronal tongue echointensity, area, height, width and height/width ratio, while MRI measures comprised sagittal T1 intensity, tongue area, position and shape. Imaging-derived markers were related to baseline and longitudinal bulbar and overall motor function. Baseline T1 intensity was lower in ALS patients with more severe bulbar involvement at baseline. Smaller baseline coronal (HRUS) and sagittal (MRI) tongue area, smaller coronal height (HRUS) and width (HRUS) as well as more rounded sagittal tongue shape predicated more rapid functional impairment - not only of bulbar, but also of overall motor function - in ALS. Our results suggest that in-vivo sonography und MRI tongue measures could aid as biomarkers to reflect bulbar and motor function impairment.
Identifiants
pubmed: 32171167
pii: S2213-1582(20)30070-X
doi: 10.1016/j.nicl.2020.102233
pmc: PMC7068685
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102233Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interests None of the authors have potential conflicts of interest to be disclosed.
Références
Lancet Neurol. 2016 Oct;15(11):1182-94
pubmed: 27647646
Radiographics. 2000 Oct;20 Spec No:S295-315
pubmed: 11046180
Neurology. 2012 Oct 2;79(14):1520
pubmed: 23033505
Ann Neurol. 1989 May;25(5):468-72
pubmed: 2774487
Nutr Hosp. 2016 Sep 20;33(5):561
pubmed: 27759965
Clin Neurophysiol. 2016 Feb;127(2):1669-1674
pubmed: 26323377
J Cachexia Sarcopenia Muscle. 2017 Oct;8(5):702-712
pubmed: 28703496
Muscle Nerve. 2016 Sep;54(3):386-90
pubmed: 26816340
Br J Radiol. 2012 Dec;85(1020):e1298-308
pubmed: 22960244
J Neurol. 2017 Apr;264(4):749-757
pubmed: 28220290
Hum Mol Genet. 2017 Mar 15;26(6):1087-1103
pubmed: 28087734
Nat Rev Neurol. 2013 Nov;9(11):617-28
pubmed: 24126629
J Neurol Sci. 1999 Oct 31;169(1-2):13-21
pubmed: 10540002
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):414-23
pubmed: 23705876
Curr Drug Targets. 2010 Oct;11(10):1250-61
pubmed: 20840067
J Neurol Sci. 1994 Jul;124 Suppl:96-107
pubmed: 7807156
J Acoust Soc Am. 2018 Apr;143(4):EL248
pubmed: 29716267
Muscle Nerve. 2009 Aug;40(2):318; author reply 319
pubmed: 19609925
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9
pubmed: 11464847
Int J Neurosci. 2019 Dec;129(12):1189-1191
pubmed: 31307259
Muscle Nerve. 2018 May;57(5):735-741
pubmed: 29105161
Neurology. 2011 Oct 18;77(16):1532-7
pubmed: 21940619
Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):133-145
pubmed: 30654671
Acta Neuropathol Commun. 2014 Dec 14;2:165
pubmed: 25510661
Clin Neurophysiol. 2008 Mar;119(3):497-503
pubmed: 18164242
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3494-501
pubmed: 20181843
Neurology. 2006 Mar 14;66(5):647-53
pubmed: 16534101
Muscle Nerve. 2015 May;51(5):669-75
pubmed: 25155020
Br J Radiol. 2013 Jun;86(1026):20120042
pubmed: 23658466
JAMA Neurol. 2013 Nov;70(11):1432-5
pubmed: 24042440
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
JCI Insight. 2018 Oct 4;3(19):
pubmed: 30282815
J Clin Med. 2018 Oct 14;7(10):
pubmed: 30322191