Bisphenol A: an emerging threat to female fertility.
BPA
Endometriosis
Fertility
Insulin resistance
Obesity
PCOS
Journal
Reproductive biology and endocrinology : RB&E
ISSN: 1477-7827
Titre abrégé: Reprod Biol Endocrinol
Pays: England
ID NLM: 101153627
Informations de publication
Date de publication:
14 Mar 2020
14 Mar 2020
Historique:
received:
01
03
2018
accepted:
19
12
2019
entrez:
16
3
2020
pubmed:
17
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Bisphenol-A (BPA) has been reported to be associated to female infertility. Indeed, BPA has been found to be more frequently detected in infertile women thus leading to hypothesize a possible effect of BPA on natural conception and spontaneous fecundity. In addition, in procedures of medically assisted reproduction BPA exposure has been found to be negatively associated with peak serum estradiol levels during gonadotropin stimulation, number of retrieved oocytes, number of normally fertilized oocytes and implantation. BPA deleterious effects are more critical during perinatal exposure, causing dysregulation of hypothalamic-pituitary-ovarian axis in pups and adults, with a precocious maturation of the axis through a damage of GnRH pulsatility, gonadotropin signaling and sex steroid hormone production. Further, BPA exposure during early lifestage may have a transgenerational effect predisposing the subsequent generations to the risk of developing BPA related disease. Experimental studies suggested that prenatal, perinatal and postnatal exposure to BPA can impair several steps of ovarian development, induce ovarian morphology rearrangement and impair ovarian function, particularly folliculogenesis, as well as can impair uterus morphology and function, in female adult animal and offspring. Finally, studies carried out in animal models have been reported the occurrence of endometriosis-like lesions after BPA exposure. Moreover, BPA exposure has been described to encourage the genesis of PCOS-like abnormalities through the impairment of the secretion of sex hormones affecting ovarian morphology and functions, particularly folliculogenesis. The current manuscript summarizes the evidence regarding the association between BPA exposure and female infertility, reviewing both clinical and preclinical studies.
Identifiants
pubmed: 32171313
doi: 10.1186/s12958-019-0558-8
pii: 10.1186/s12958-019-0558-8
pmc: PMC7071611
doi:
Substances chimiques
Benzhydryl Compounds
0
Endocrine Disruptors
0
Phenols
0
bisphenol A
MLT3645I99
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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