New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
COVID-19
Chloroquine
Coronavirus
SARS-CoV-2
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
02
03
2020
revised:
03
03
2020
accepted:
05
03
2020
pubmed:
17
3
2020
medline:
29
5
2020
entrez:
16
3
2020
Statut:
ppublish
Résumé
Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.
Identifiants
pubmed: 32171740
pii: S0924-8579(20)30088-1
doi: 10.1016/j.ijantimicag.2020.105938
pmc: PMC7118659
pii:
doi:
Substances chimiques
Antiviral Agents
0
Chloroquine
886U3H6UFF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105938Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
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