Expeditious and eco-friendly synthesis of new multifunctionalized pyrrole derivatives and evaluation of their antioxidant property.
Antioxidants
/ chemical synthesis
Biphenyl Compounds
/ antagonists & inhibitors
Dose-Response Relationship, Drug
Hydroxyl Radical
/ antagonists & inhibitors
Molecular Structure
Oxidative Stress
/ drug effects
Picrates
/ antagonists & inhibitors
Pyrroles
/ chemical synthesis
Structure-Activity Relationship
Antioxidants
Multicomponent domino reaction
Pyrrole derivatives
Pyrrole-coumarin conjugates
ROS scavengers
Reductants
Silica sulfuric acid (SSA) as heterogeneous acid catalyst
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
09
12
2019
revised:
24
02
2020
accepted:
06
03
2020
pubmed:
17
3
2020
medline:
25
2
2021
entrez:
16
3
2020
Statut:
ppublish
Résumé
Diminution of oxidative stress-mediated diseases is an essential pharmaceutical objective in modern biomedical research. The present work stresses upon the efficient and eco-friendly synthesis of an array of novel diversely functionalized pyrrole derivatives which are found to be antioxidants with reactive oxygen species (ROS) shielding competency against the deleterious consequence of oxidative stress. The results of the investigation displayed the effect of structural modification of the pyrrole derivatives on their respective antioxidant properties to various ROS. Noteworthy, the pyrrole moiety bearing 4-hydroxycoumarin or 2-hydroxy-1,4-naphthoquinone as substituent showed outstanding defensive potency towards OH and O
Identifiants
pubmed: 32171990
pii: S0045-2068(19)32109-1
doi: 10.1016/j.bioorg.2020.103734
pii:
doi:
Substances chimiques
Antioxidants
0
Biphenyl Compounds
0
Picrates
0
Pyrroles
0
Hydroxyl Radical
3352-57-6
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103734Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.