Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala.
Adult
Agricultural Workers' Diseases
/ diagnosis
Biomarkers
/ blood
Dehydration
/ blood
Glycopeptides
/ blood
Guatemala
/ epidemiology
Hot Temperature
/ adverse effects
Humans
Kidney
/ physiopathology
Kidney Function Tests
Longitudinal Studies
Male
Neurophysins
/ blood
Occupational Exposure
/ adverse effects
Prevalence
Prognosis
Prospective Studies
Protein Precursors
/ blood
Renal Insufficiency, Chronic
/ diagnosis
Saccharum
Vasopressins
/ blood
Agricultural workers
Hydration
Kidney
Vasopressin
Journal
Annals of nutrition & metabolism
ISSN: 1421-9697
Titre abrégé: Ann Nutr Metab
Pays: Switzerland
ID NLM: 8105511
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
12
2019
accepted:
16
02
2020
pubmed:
17
3
2020
medline:
29
5
2021
entrez:
16
3
2020
Statut:
ppublish
Résumé
Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. Utilizing a longitudinal study of 105 workers in Guatemala, we examined relationships between hydration indices, plasma copeptin concentrations, and kidney function markers at 3 times during the 6-month harvest. We also examined whether baseline copeptin concentrations increased the odds of developing an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Copeptin concentrations were positively associated with serum creatinine (β 1.41, 95% CI 0.88-2.03) and negatively associated with eGFR (β -1.07, 95% CI -1.43 to -0.70). In addition, as workers improved their hydration (measured by increases in fluid balance), copeptin concentrations were reduced, and this reduction was associated with an improvement in kidney function. Results suggest that copeptin should be studied as a potential prognostic biomarker.
Sections du résumé
BACKGROUND
Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions.
METHODS
Utilizing a longitudinal study of 105 workers in Guatemala, we examined relationships between hydration indices, plasma copeptin concentrations, and kidney function markers at 3 times during the 6-month harvest. We also examined whether baseline copeptin concentrations increased the odds of developing an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2.
RESULTS
Copeptin concentrations were positively associated with serum creatinine (β 1.41, 95% CI 0.88-2.03) and negatively associated with eGFR (β -1.07, 95% CI -1.43 to -0.70). In addition, as workers improved their hydration (measured by increases in fluid balance), copeptin concentrations were reduced, and this reduction was associated with an improvement in kidney function.
CONCLUSIONS
Results suggest that copeptin should be studied as a potential prognostic biomarker.
Identifiants
pubmed: 32172243
pii: 000506619
doi: 10.1159/000506619
pmc: PMC7212520
mid: NIHMS1573672
doi:
Substances chimiques
AVP protein, human
0
Biomarkers
0
Glycopeptides
0
Neurophysins
0
Protein Precursors
0
copeptins
0
Vasopressins
11000-17-2
Types de publication
Evaluation Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
30-36Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES028826
Pays : United States
Organisme : NIOSH CDC HHS
ID : U19 OH011227
Pays : United States
Informations de copyright
© 2020 S. Karger AG, Basel.
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