Growth-Promoting Treatment Screening for Corticospinal Neurons in Mouse and Man.
Corticospinal tract
Growth-promoting treatment
Interleukin-4
Regeneration
Spinal cord injury
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
16
10
2019
accepted:
20
02
2020
pubmed:
17
3
2020
medline:
22
6
2021
entrez:
16
3
2020
Statut:
ppublish
Résumé
Neurons of the central nervous system (CNS) that project long axons into the spinal cord have a poor axon regenerative capacity compared to neurons of the peripheral nervous system. The corticospinal tract (CST) is particularly notorious for its poor regeneration. Because of this, traumatic spinal cord injury (SCI) is a devastating condition that remains as yet uncured. Based on our recent observations that direct neuronal interleukin-4 (IL-4) signaling leads to repair of axonal swellings and beneficial effects in neuroinflammation, we hypothesized that IL-4 acts directly on the CST. Here, we developed a tissue culture model for CST regeneration and found that IL-4 promoted new growth cone formation after axon transection. Most importantly, IL-4 directly increased the regenerative capacity of both murine and human CST axons, which corroborates its regenerative effects in CNS damage. Overall, these findings serve as proof-of-concept that our CST regeneration model is suitable for fast screening of new treatments for SCI.
Identifiants
pubmed: 32172457
doi: 10.1007/s10571-020-00820-7
pii: 10.1007/s10571-020-00820-7
pmc: PMC7497511
doi:
Substances chimiques
PTEN Phosphohydrolase
EC 3.1.3.67
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1327-1338Subventions
Organisme : Progressive MS alliance
ID : PA-1604-08492
Organisme : Gemeinnützige Hertie-Stiftung
ID : P1180009
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC-TR-128
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC1080
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