Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review.
Acute pain
Clinical studies
Combination analgesic drugs
Efficacy
Low-dose codeine
Review
Safety
Substance-use disorder
Journal
Pain and therapy
ISSN: 2193-8237
Titre abrégé: Pain Ther
Pays: New Zealand
ID NLM: 101634491
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
02
02
2020
pubmed:
17
3
2020
medline:
17
3
2020
entrez:
16
3
2020
Statut:
ppublish
Résumé
The objective of this systematic review is to reflect on assumptions in relation to codeine use in combination with other analgesics. MEDLINE was searched according to the predetermined keywords and criteria. Only English language studies were taken into consideration and the outcome data of the final studies were extracted by two reviewers independently from each other and were checked by the third reviewer. Additionally, the available codeine-related Individual Case Safety Reports (ICSRs) retrieved from EudraVigilance were reviewed. Sixteen placebo-controlled studies that involved 3378 subjects suffering from acute pain were analyzed for the efficacy of low-dose codeine (≤ 30 mg) combination products. Twelve of them found low-dose codeine combinations more efficient in relieving pain than the assigned comparator. According to 20 randomized clinical trials which included at least one dose of codeine (from 30 to 240 mg daily), the vast majority of reported side-effects were mild or moderate in severity. A total of 20 ICSRs for dependence were identified in the EudraVigilance database with codeine as a suspect drug for the 10-year time period for the European region. Low-dose codeine combinations are effective after a single application in treating acute pain. Codeine in doses ≤ 30 mg and higher was considered safe since only mild to moderate side-effects were observed. There is no indication in the available sources which clearly links low doses of codeine to substance use disorder in non-dependent subjects.
Identifiants
pubmed: 32172479
doi: 10.1007/s40122-020-00162-8
pii: 10.1007/s40122-020-00162-8
pmc: PMC7203384
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
171-194Références
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