The hydrogel of whey protein isolate coated by lotus root amylopectin enhance the stability and bioavailability of quercetin.
Encapsulation
Hydrogels
Lotus rootamylopectin
Quercetin
Whey protein isolate
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
10
12
2019
revised:
08
02
2020
accepted:
13
02
2020
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
24
11
2020
Statut:
ppublish
Résumé
In this study, whey protein isolate (WPI)-quercetin (Que)-lotus root amylopectin (LRA) hydrogels (WPI-QUE-LRA) was developed to improve the solubility, stability and bioavailability of quercetin. Results showed that the favorable WPI-QUE-LRA was formed using WPI and LRA in the ratio of 1:2 at pH 7.0. Under this condition, the average size, polydispersity index, zeta potential of the WPI-QUE-LRA was 179.5 nm, 0.271, -18.6 mV, respectively. The analysis of transmission electron microscopy, fourier transform infrared spectroscopy and X-ray diffractometer revealed that the quercetin was successfully encapsulated in WPI-LRA, giving a high encapsulation efficiency of 92.4 %. Moreover, the WPI-LRA could significantly improve the storage stability and photochemical stability of quercetin. The in vitro and in vivo experiments showed that LRA-coated WPI hydrogel can enable quercetin to be stable in stomach and be effectively released in small intestine, leading to the enhancement of the bioavailability of quercetin.
Identifiants
pubmed: 32172837
pii: S0144-8617(20)30183-1
doi: 10.1016/j.carbpol.2020.116009
pii:
doi:
Substances chimiques
Drug Carriers
0
Hydrogels
0
Whey Proteins
0
Amylopectin
9037-22-3
Quercetin
9IKM0I5T1E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116009Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.