The key role of oncopharmacology in therapeutic management, from common to rare cancers: A literature review.
Immunotherapies
Oncopharmacology
Pharmacogenomics
Resistance
Targeted therapies
Therapeutic drug monitoring
Journal
Therapie
ISSN: 1958-5578
Titre abrégé: Therapie
Pays: France
ID NLM: 0420544
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
16
09
2019
accepted:
15
11
2019
pubmed:
17
3
2020
medline:
20
2
2021
entrez:
17
3
2020
Statut:
ppublish
Résumé
The therapeutic management of cancers has undergone considerable changes due to the emergence of genomics tools and tumor molecular deciphering. In this context, a dual pharmacological approach based on pharmacogenomic analyses and therapeutic drug monitoring is now part of the routine care in cancer management for personalized therapies. First, molecular and immune profiling of tumors allows the emergence of new pharmacological targets in common as well as in rare cancers. Second, pharmacogenomic analyses coupled to therapeutic drug monitoring guide the prescription by adjusting regimen and managing drug resistance.
Identifiants
pubmed: 32173061
pii: S0040-5957(20)30015-9
doi: 10.1016/j.therap.2020.02.010
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
183-193Informations de copyright
Copyright © 2020 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.