Well-Differentiated Papillary Mesothelioma With Two Synchronous Serous Gynaecologic Carcinomas in a 62-Year-Old Woman: Lessons Learned for the Gynaecologic Surgeon.
Antineoplastic Agents
/ therapeutic use
Carboplatin
/ therapeutic use
Cystadenocarcinoma, Serous
/ pathology
Endometrial Neoplasms
Female
Genital Neoplasms, Female
/ pathology
Humans
Hysterectomy
Mesothelioma
/ pathology
Middle Aged
Paclitaxel
/ therapeutic use
Pelvic Bones
/ diagnostic imaging
Treatment Outcome
cystic
mesothelioma
ovarian neoplasms
uterine neoplasms
Journal
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
ISSN: 1701-2163
Titre abrégé: J Obstet Gynaecol Can
Pays: Netherlands
ID NLM: 101126664
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
09
09
2019
revised:
07
12
2019
accepted:
10
12
2019
pubmed:
17
3
2020
medline:
29
6
2021
entrez:
17
3
2020
Statut:
ppublish
Résumé
Well-differentiated papillary mesothelioma (WDPM) is a rare tumor of unknown malignant potential. It is typically diagnosed incidentally during benign gynaecologic surgery. We report the first published case of WDPM in a woman with synchronous serous carcinomas of the gynaecologic tract and highlight lessons learned for general gynaecologists and gynaecologic oncologists alike. A 62-year-old woman was referred for assessment and management of a pelvic mass. Intraoperatively, metastatic high-grade carcinoma was identified and the patient underwent a successful debulking procedure that identified 3 synchronous tumors: ovarian high-grade serous carcinoma, endometrial serous carcinoma, and 2 foci of pelvic WDPM. This case of WDPM with 2 synchronous serous gynaecologic tumors is a novel addition to the reported literature and offers many learning points about the disease. Gynaecologic surgeons should be familiar with WDPM, as it is predominantly found in reproductive-aged women undergoing benign gynaecologic surgery, may be linked with endometriosis, and has an unclear malignant potential. Multidisciplinary care is essential for accurate diagnosis. Further research is needed to clarify the optimal management and surveillance of WDPM.
Sections du résumé
BACKGROUND
BACKGROUND
Well-differentiated papillary mesothelioma (WDPM) is a rare tumor of unknown malignant potential. It is typically diagnosed incidentally during benign gynaecologic surgery. We report the first published case of WDPM in a woman with synchronous serous carcinomas of the gynaecologic tract and highlight lessons learned for general gynaecologists and gynaecologic oncologists alike.
CASE
METHODS
A 62-year-old woman was referred for assessment and management of a pelvic mass. Intraoperatively, metastatic high-grade carcinoma was identified and the patient underwent a successful debulking procedure that identified 3 synchronous tumors: ovarian high-grade serous carcinoma, endometrial serous carcinoma, and 2 foci of pelvic WDPM.
CONCLUSION
CONCLUSIONS
This case of WDPM with 2 synchronous serous gynaecologic tumors is a novel addition to the reported literature and offers many learning points about the disease. Gynaecologic surgeons should be familiar with WDPM, as it is predominantly found in reproductive-aged women undergoing benign gynaecologic surgery, may be linked with endometriosis, and has an unclear malignant potential. Multidisciplinary care is essential for accurate diagnosis. Further research is needed to clarify the optimal management and surveillance of WDPM.
Identifiants
pubmed: 32173236
pii: S1701-2163(20)30011-6
doi: 10.1016/j.jogc.2019.12.012
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Carboplatin
BG3F62OND5
Paclitaxel
P88XT4IS4D
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1262-1266Informations de copyright
Copyright © 2020 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.