Wnt-regulating microRNAs role in gastric cancer malignancy.
Apoptosis
Cell Differentiation
Cell Line, Tumor
Cell Movement
/ genetics
Cell Nucleus
/ metabolism
Cell Proliferation
Cytoplasm
/ metabolism
Gene Expression Regulation, Neoplastic
Humans
Ligands
MicroRNAs
/ metabolism
Protein Transport
Signal Transduction
Stomach Neoplasms
/ metabolism
Wnt Signaling Pathway
beta Catenin
/ metabolism
Cancer therapy
Gastric cancer
MicroRNAs
Signaling pathway
Wnt
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
received:
11
01
2020
revised:
06
03
2020
accepted:
11
03
2020
pubmed:
17
3
2020
medline:
6
5
2020
entrez:
17
3
2020
Statut:
ppublish
Résumé
Gastric cancer (GC) is responsible for high morbidity and mortality worldwide. This cancer claims fifth place among other cancers. There are a number of factors associated with GC development such as alcohol consumption and tobacco smoking. It seems that genetic factors play significant role in GC malignancy and progression. MicroRNAs (miRs) are short non-coding RNA molecules with negative impact on the expression of target genes. A variety of studies have elucidated the potential role of miRs in GC growth. Investigation of molecular pathways has revealed that miRs function as upstream modulators of Wnt signaling pathway. This signaling pathway involves in important biological processes such as cell proliferation and differentiation, and its dysregulation is associated with GC invasion. At the present review, we demonstrate that how miRs regulate Wnt signaling pathway in GC malignancy.
Identifiants
pubmed: 32173311
pii: S0024-3205(20)30295-2
doi: 10.1016/j.lfs.2020.117547
pii:
doi:
Substances chimiques
CTNNB1 protein, human
0
Ligands
0
MicroRNAs
0
beta Catenin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
117547Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.