Biparental care in C57BL/6J mice: effects on adolescent behavior and alcohol consumption.
Adolescent
Alcohol
Maternal behavior
Parenting
Paternal behavior
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
20
09
2019
accepted:
05
03
2020
pubmed:
17
3
2020
medline:
30
9
2020
entrez:
17
3
2020
Statut:
ppublish
Résumé
Social attachment plays an important role in offspring development. Different parenting experiences during lactation may shape offspring behavior and later alcohol use. We tested the hypothesis that differential rearing conditions (single mother, SM or biparental, BP) in the non-monogamous C57BL/6J mice may affect (1) parental behavior during lactation, (2) adolescent behavior, and (3) adolescent initiation of alcohol drinking. Mice were reared in SM or BP (cohabitation of father-mother since copulation) condition until weaning (postnatal day, PND, 21). Litters from both conditions were filmed during PNDs 6, 9, and 12 and an ethogram was made taking into account nest-, pup-, or self-directed behaviors. At PNDs, 28-29 adolescent animals were evaluated in a modified version of the concentric square field for measurement of behavioral patterns. Other groups of adolescents were tested in a 4-h daily, two-bottle choice alcohol consumption test (10% alcohol vs. water) during 3 weeks (4 days per week). Single mothers spent less time in the nest, left unattended the nest more times, displayed more self-directed and less pup-directed behaviors than BP parents. SM-reared adolescents displayed more anxiogenic-like and less risk-associated behaviors than BP counterparts. The alcohol consumption test indicated a strong effect of rearing condition. Since the fifth day of test, SM adolescents consumed more quantities of alcohol than BP adolescents. During single-mother parenting, pups are left unattended more often, and during adolescence, these organisms exhibited increased anxiety responses. This behavioral phenotype may act as a risk factor for alcohol initiation during adolescence.
Identifiants
pubmed: 32173769
doi: 10.1007/s00213-020-05501-3
pii: 10.1007/s00213-020-05501-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1841-1850Subventions
Organisme : Fondo para la Investigación Científica y Tecnológica
ID : PICT 2016-2461
Organisme : Fondo para la Investigación Científica y Tecnológica
ID : PICT 2014-1606
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