Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood.
Alzheimer's Disease
Amyloid-beta Peptides
Biomarkers
Diagnostic Techniques and Procedures
Plasma
tau Proteins
Journal
Dementia and neurocognitive disorders
ISSN: 2384-0757
Titre abrégé: Dement Neurocogn Disord
Pays: Korea (South)
ID NLM: 101600298
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
04
09
2019
revised:
02
12
2019
accepted:
09
12
2019
pubmed:
17
3
2020
medline:
17
3
2020
entrez:
17
3
2020
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms. Many efforts have been made to develop a blood-based diagnostic method for AD by incorporating Aβ and tau as plasma biomarkers. As blood tests have the advantages of being highly accessible and low cost, clinical implementation of AD blood tests would provide preventative screening to presymptomatic individuals, facilitating early identification of AD patients and, thus, treatment development in clinical research. However, the low concentration of AD biomarkers in the plasma has posed difficulties for accurate detection, hindering the development of a reliable blood test. In this review, we introduce three AD blood test technologies emerging in South Korea, which have distinctive methods of heightening detection sensitivity of specific plasma biomarkers. We discuss in detail the multimer detection system, the self-standard analysis of Aβ biomarkers quantified by interdigitated microelectrodes, and a biomarker ratio analysis comprising Aβ and tau.
Identifiants
pubmed: 32174051
doi: 10.12779/dnd.2020.19.1.1
pii: 19.e5
pmc: PMC7105719
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1-18Subventions
Organisme : Korea Health Industry Development Institute
ID : HI14C3319
Pays : Republic of Korea
Organisme : National Research Foundation of Korea
ID : NRF-2018R1A6A1A03023718
Pays : Korea
Organisme : National Research Foundation of Korea
ID : NRF-2018M3C7A1021858
Pays : Korea
Organisme : Yonsei University
ID : 2018-22-0022
Pays : Korea
Informations de copyright
© 2020 Korean Dementia Association.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest.
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